DegronMD

Uniprot ID: Q63HQ0

Source protein: AP-1 complex-associated regulatory protein

Source gene: AP1AR

Class: DEG_SCF_FBW7_2

Location: 179:185

E3 ligase: FBXW7

DEGRON score: 0.9931

ASA_SCORE: 92.3714

COIL: 0.8774

CONS_SCORE: 0.949

DSS_SCORE: 0.5026

HELIX: 0.0563

FCONS_SCORE: 1.0944

RIG_SCORE: 0.7133

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R169Q	TCGA-AP-A056	UCEC	TCGA	VLTPNTE	DEG_SCF_FBW7_2	0.0556
p.R169Q	TCGA-FI-A2D5	UCEC	TCGA	VLTPNTE	DEG_SCF_FBW7_2	0.0556
p.R172G	TCGA-DI-A1BU	UCEC	TCGA	VLTPNTE	DEG_SCF_FBW7_2	0.1389
p.R172G	DO42023	UCEC	ICGC	VLTPNTE	DEG_SCF_FBW7_2	0.1389
p.R192C	DO13863	GBM	ICGC	VLTPNTE	DEG_SCF_FBW7_2	0.1389
p.R192C	DO43041	UCEC	ICGC	VLTPNTE	DEG_SCF_FBW7_2	0.1389
p.R192C	DO41331	UCEC	ICGC	VLTPNTE	DEG_SCF_FBW7_2	0.1389
p.S187I	DO229026	LICA	ICGC	VLTPNTE	DEG_SCF_FBW7_2	0.7222
p.S174L	DO222662	MELA	ICGC	VLTPNTE	DEG_SCF_FBW7_2	0.6389
p.N184H	DO51407	PRAD	ICGC	VLTPNTE	DEG_SCF_FBW7_2	0.7423
p.P188Q	DO37715	SKCM	ICGC	VLTPNTE	DEG_SCF_FBW7_2	0.25
p.P188Q	DO51236	SKCM	ICGC	VLTPNTE	DEG_SCF_FBW7_2	0.25
p.K193E	SIDM00542	Glioblastoma	GDSC	VLTPNTE	DEG_SCF_FBW7_2	0.2222
p.K193E	ACH-002227	Brain Cancer	CCLE	VLTPNTE	DEG_SCF_FBW7_2	0.2222
p.K193E	D-392MG	central_nervous_system	COSMIC	VLTPNTE	DEG_SCF_FBW7_2	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q63HQ0	AP-1 complex-associated regulatory protein	DEG_SCF_FBW7_2	179:185	VLTPNTE	FBXW7	0.9931	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons