DegronMD

Uniprot ID: Q2V2M9

Source protein: FH1/FH2 domain-containing protein 3

Source gene: FHOD3

Class: DEG_SCF_TRCP1_1

Location: 1283:1288

E3 ligase: BTRC

DEGRON score: 0.5565

ASA_SCORE: 93.7667

COIL: 0.8925

CONS_SCORE: 0.3964

DSS_SCORE: 0.7593

HELIX: 0.0742

FCONS_SCORE: 0.8976

RIG_SCORE: 0.5828

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1285S	TCGA-55-6972	LUAD	TCGA	DSGKFS	DEG_SCF_TRCP1_1	0.7588
p.Q1282H	TCGA-A5-A2K5	UCEC	TCGA	DSGKFS	DEG_SCF_TRCP1_1	0.3056
p.R1288T	TCGA-AA-3947	COAD	TCGA	DSGKFS	DEG_SCF_TRCP1_1	0.7876
p.R1288T	TCGA-B5-A0JZ	UCEC	TCGA	DSGKFS	DEG_SCF_TRCP1_1	0.7876
p.R1288T	TCGA-D1-A101	UCEC	TCGA	DSGKFS	DEG_SCF_TRCP1_1	0.7876
p.R1274S	TCGA-D3-A1QA	SKCM	TCGA	DSGKFS	DEG_SCF_TRCP1_1	0.0833
p.H1287Y	TCGA-E9-A245	BRCA	TCGA	DSGKFS	DEG_SCF_TRCP1_1	0.7229
p.A1284V	SIDM00405	B-Cell Non-Hodgkin's Lymphoma	GDSC	DSGKFS	DEG_SCF_TRCP1_1	0.6936
p.A1284V	ACH-000365	Lymphoma	CCLE	DSGKFS	DEG_SCF_TRCP1_1	0.6936
p.A1284V	SU-DHL-4	haematopoietic_and_lymphoid_tissue	COSMIC	DSGKFS	DEG_SCF_TRCP1_1	0.6936
p.L1283F	SIDM00845	Burkitt's Lymphoma	GDSC	DSGKFS	DEG_SCF_TRCP1_1	0.6981
p.I1285M	ACH-001277	Sarcoma	CCLE	DSGKFS	DEG_SCF_TRCP1_1	0.7618
p.R1284Q	HCC2998	large_intestine	COSMIC	DSGKFS	DEG_SCF_TRCP1_1	0.7329
p.K1296N	HT-115	large_intestine	COSMIC	DSGKFS	DEG_SCF_TRCP1_1	0.5556
p.R1284W	DU-145	prostate	COSMIC	DSGKFS	DEG_SCF_TRCP1_1	0.8634
p.K1279N	HT-115	large_intestine	COSMIC	DSGKFS	DEG_SCF_TRCP1_1	0.3333

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q2V2M9	FH1/FH2 domain-containing protein 3	DEG_SCF_TRCP1_1	1283:1288	DSGKFS	BTRC	0.5565	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons