DegronMD - Q2V2M9(FHOD3)

FUNCTION: Actin-organizing protein that may cause stress fiber formation together with cell elongation (By similarity). Isoform 4 may play a role in actin filament polymerization in cardiomyocytes. {ECO:0000250, ECO:0000269|PubMed:21149568}.

GO - Biological processes (BP): actin filament network formation [GO:0051639]; cardiac myofibril assembly [GO:0055003]; cortical actin cytoskeleton organization [GO:0030866]; negative regulation of actin filament polymerization [GO:0030837]; sarcomere organization [GO:0045214]

GO - Molecular function (MF): actin filament binding [GO:0051015]

GO - Cellular component (CC): cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; Z disc [GO:0030018]

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Show entries

Search:

Degron hit	Class	E3 ligase	Source protein	Location	Detail
VPTTPTSS	DEG_SCF_FBW7_1	FBXW7	FH1/FH2 domain-containing protein 3	419:426	More..
DSGKFS	DEG_SCF_TRCP1_1	BTRC	FH1/FH2 domain-containing protein 3	1283:1288	More..
VSSSS	DEG_SPOP_SBC_1	SPOP	FH1/FH2 domain-containing protein 3	630:634	More..

Showing 1 to 3 of 3 entries

Previous1Next

Show entries

Search:

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S426F	TCGA-3N-A9WB	SKCM	TCGA	VPTTPTSS	DEG_SCF_FBW7_1	419:426	Mutation altering degron motif	0.9093
p.R631W	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	VSSSS	DEG_SPOP_SBC_1	630:634	Mutation altering degron motif	0.8634
p.R1284W	DU-145	prostate	COSMIC	DSGKFS	DEG_SCF_TRCP1_1	1283:1288	Mutation altering degron motif	0.8634
p.S423F	DO47268	SKCM	ICGC	VPTTPTSS	DEG_SCF_FBW7_1	419:426	Mutation altering degron motif	0.7982
p.R1288T	TCGA-AA-3947	COAD	TCGA	DSGKFS	DEG_SCF_TRCP1_1	1283:1288	Mutation altering degron motif	0.7876
p.R1288T	TCGA-B5-A0JZ	UCEC	TCGA	DSGKFS	DEG_SCF_TRCP1_1	1283:1288	Mutation altering degron motif	0.7876
p.R1288T	TCGA-D1-A101	UCEC	TCGA	DSGKFS	DEG_SCF_TRCP1_1	1283:1288	Mutation altering degron motif	0.7876
p.I1285M	ACH-001277	Sarcoma	CCLE	DSGKFS	DEG_SCF_TRCP1_1	1283:1288	Mutation altering degron motif	0.7618
p.A1285S	TCGA-55-6972	LUAD	TCGA	DSGKFS	DEG_SCF_TRCP1_1	1283:1288	Mutation altering degron motif	0.7588
p.A631S	DO229015	LICA	ICGC	VSSSS	DEG_SPOP_SBC_1	630:634	Mutation altering degron motif	0.7588
p.Q425H	DO229218	THCA	ICGC	VPTTPTSS	DEG_SCF_FBW7_1	419:426	Mutation altering degron motif	0.7582
p.R631S	TCGA-AR-A1AY	BRCA	TCGA	VSSSS	DEG_SPOP_SBC_1	630:634	Mutation altering degron motif	0.7427
p.R1284Q	HCC2998	large intestine	COSMIC	DSGKFS	DEG_SCF_TRCP1_1	1283:1288	Mutation altering degron motif	0.7329
p.H1287Y	TCGA-E9-A245	BRCA	TCGA	DSGKFS	DEG_SCF_TRCP1_1	1283:1288	Mutation altering degron motif	0.7229
p.C424F	DO229027	LICA	ICGC	VPTTPTSS	DEG_SCF_FBW7_1	419:426	Mutation altering degron motif	0.7108
p.T422P	NCI-H1876	lung	COSMIC	VPTTPTSS	DEG_SCF_FBW7_1	419:426	Mutation altering degron motif	0.7031
p.L1283F	SIDM00845	Burkitt's Lymphoma	GDSC	DSGKFS	DEG_SCF_TRCP1_1	1283:1288	Mutation altering degron motif	0.6981
p.A1284V	SIDM00405	B-Cell Non-Hodgkin's Lymphoma	GDSC	DSGKFS	DEG_SCF_TRCP1_1	1283:1288	Mutation altering degron motif	0.6936
p.A1284V	ACH-000365	Lymphoma	CCLE	DSGKFS	DEG_SCF_TRCP1_1	1283:1288	Mutation altering degron motif	0.6936
p.A1284V	SU-DHL-4	haematopoietic and lymphoid tissue	COSMIC	DSGKFS	DEG_SCF_TRCP1_1	1283:1288	Mutation altering degron motif	0.6936

Showing 1 to 20 of 57 entries

Previous1 2 3Next

Kaplan plot for FHOD3 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FHOD3

UniProt ID: Q2V2M9

Entrez ID: 80206

Protein name: FH1/FH2 domain-containing protein 3 (Formactin-2) (Formin homolog overexpressed in spleen 2) (hFHOS2)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for FHOD3 in