DegronMD - Q2V2M9(FHOD3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S426F	TCGA-3N-A9WB	SKCM	TCGA	VPTTPTSS	DEG_SCF_FBW7_1	419:426	Mutation altering degron motif	0.9093
p.A1285S	TCGA-55-6972	LUAD	TCGA	DSGKFS	DEG_SCF_TRCP1_1	1283:1288	Mutation altering degron motif	0.7588
p.Q1282H	TCGA-A5-A2K5	UCEC	TCGA	DSGKFS	DEG_SCF_TRCP1_1	1283:1288	Mutation rewiring degron network	0.3056
p.R1288T	TCGA-AA-3947	COAD	TCGA	DSGKFS	DEG_SCF_TRCP1_1	1283:1288	Mutation altering degron motif	0.7876
p.R1288T	TCGA-B5-A0JZ	UCEC	TCGA	DSGKFS	DEG_SCF_TRCP1_1	1283:1288	Mutation altering degron motif	0.7876
p.R1288T	TCGA-D1-A101	UCEC	TCGA	DSGKFS	DEG_SCF_TRCP1_1	1283:1288	Mutation altering degron motif	0.7876
p.E638K	TCGA-AA-3984	COAD	TCGA	VSSSS	DEG_SPOP_SBC_1	630:634	Mutation rewiring degron network	0.2222
p.E638K	TCGA-AA-A00N	COAD	TCGA	VSSSS	DEG_SPOP_SBC_1	630:634	Mutation rewiring degron network	0.2222
p.E638K	HT-115	large intestine	COSMIC	VSSSS	DEG_SPOP_SBC_1	630:634	Mutation rewiring degron network	0.2222
p.R631S	TCGA-AR-A1AY	BRCA	TCGA	VSSSS	DEG_SPOP_SBC_1	630:634	Mutation altering degron motif	0.7427
p.P413S	TCGA-BG-A0M4	UCEC	TCGA	VPTTPTSS	DEG_SCF_FBW7_1	419:426	Mutation rewiring degron network	0.1667
p.V427I	TCGA-BS-A0V4	UCEC	TCGA	VPTTPTSS	DEG_SCF_FBW7_1	419:426	Mutation rewiring degron network	0.3056
p.K629I	TCGA-CZ-5460	KIRC	TCGA	VSSSS	DEG_SPOP_SBC_1	630:634	Mutation rewiring degron network	0.3056
p.R1274S	TCGA-D3-A1QA	SKCM	TCGA	DSGKFS	DEG_SCF_TRCP1_1	1283:1288	Mutation rewiring degron network	0.0833
p.E621Q	TCGA-DS-A1OC	CESC	TCGA	VSSSS	DEG_SPOP_SBC_1	630:634	Mutation rewiring degron network	0.0833
p.H1287Y	TCGA-E9-A245	BRCA	TCGA	DSGKFS	DEG_SCF_TRCP1_1	1283:1288	Mutation altering degron motif	0.7229
p.S621L	DO51906	BLCA	ICGC	VSSSS	DEG_SPOP_SBC_1	630:634	Mutation rewiring degron network	0.0833
p.E640K	DO51900	BLCA	ICGC	VSSSS	DEG_SPOP_SBC_1	630:634	Mutation rewiring degron network	0.1667
p.R637W	DO10012	COAD	ICGC	VSSSS	DEG_SPOP_SBC_1	630:634	Mutation rewiring degron network	0.25
p.R637W	DO13462	GBM	ICGC	VSSSS	DEG_SPOP_SBC_1	630:634	Mutation rewiring degron network	0.25
p.R637W	DO41139	UCEC	ICGC	VSSSS	DEG_SPOP_SBC_1	630:634	Mutation rewiring degron network	0.25
p.R638L	DO14284	HNSC	ICGC	VSSSS	DEG_SPOP_SBC_1	630:634	Mutation rewiring degron network	0.2222
p.V431F	DO228976	LICA	ICGC	VPTTPTSS	DEG_SCF_FBW7_1	419:426	Mutation rewiring degron network	0.1944
p.A631S	DO229015	LICA	ICGC	VSSSS	DEG_SPOP_SBC_1	630:634	Mutation altering degron motif	0.7588
p.C424F	DO229027	LICA	ICGC	VPTTPTSS	DEG_SCF_FBW7_1	419:426	Mutation altering degron motif	0.7108
p.R624W	DO23525	LIRI	ICGC	VSSSS	DEG_SPOP_SBC_1	630:634	Mutation rewiring degron network	0.1667
p.E628Q	DO27699	LUSC	ICGC	VSSSS	DEG_SPOP_SBC_1	630:634	Mutation rewiring degron network	0.2778
p.E411D	DO227603	ORCA	ICGC	VPTTPTSS	DEG_SCF_FBW7_1	419:426	Mutation blocking phosphorylation signal	0.5556
p.S423F	DO47268	SKCM	ICGC	VPTTPTSS	DEG_SCF_FBW7_1	419:426	Mutation altering degron motif	0.7982
p.A433P	DO229272	THCA	ICGC	VPTTPTSS	DEG_SCF_FBW7_1	419:426	Mutation rewiring degron network	0.1389
p.Q425H	DO229218	THCA	ICGC	VPTTPTSS	DEG_SCF_FBW7_1	419:426	Mutation altering degron motif	0.7582
p.A433T	DO229221	THCA	ICGC	VPTTPTSS	DEG_SCF_FBW7_1	419:426	Mutation rewiring degron network	0.1389
p.R638Q	DO39962	THCA	ICGC	VSSSS	DEG_SPOP_SBC_1	630:634	Mutation rewiring degron network	0.2222
p.A1284V	SIDM00405	B-Cell Non-Hodgkin's Lymphoma	GDSC	DSGKFS	DEG_SCF_TRCP1_1	1283:1288	Mutation altering degron motif	0.6936
p.A1284V	ACH-000365	Lymphoma	CCLE	DSGKFS	DEG_SCF_TRCP1_1	1283:1288	Mutation altering degron motif	0.6936
p.A1284V	SU-DHL-4	haematopoietic and lymphoid tissue	COSMIC	DSGKFS	DEG_SCF_TRCP1_1	1283:1288	Mutation altering degron motif	0.6936
p.L1283F	SIDM00845	Burkitt's Lymphoma	GDSC	DSGKFS	DEG_SCF_TRCP1_1	1283:1288	Mutation altering degron motif	0.6981
p.R638W	SIDM00244	Neuroblastoma	GDSC	VSSSS	DEG_SPOP_SBC_1	630:634	Mutation rewiring degron network	0.2222
p.R644K	SIDM01608	Endometrial Carcinoma	GDSC	VSSSS	DEG_SPOP_SBC_1	630:634	Mutation rewiring degron network	0.0556
p.R644K	ACH-000990	Endometrial/Uterine Cancer	CCLE	VSSSS	DEG_SPOP_SBC_1	630:634	Mutation rewiring degron network	0.0556
p.I1285M	ACH-001277	Sarcoma	CCLE	DSGKFS	DEG_SCF_TRCP1_1	1283:1288	Mutation altering degron motif	0.7618
p.P430R	HCE-4	oesophagus	COSMIC	VPTTPTSS	DEG_SCF_FBW7_1	419:426	Mutation rewiring degron network	0.2222
p.E621K	HT-115	large intestine	COSMIC	VSSSS	DEG_SPOP_SBC_1	630:634	Mutation rewiring degron network	0.0833
p.S631L	DND-41	haematopoietic and lymphoid tissue	COSMIC	VSSSS	DEG_SPOP_SBC_1	630:634	Mutation altering degron motif	0.6556
p.S411A	CCK-81	large intestine	COSMIC	VPTTPTSS	DEG_SCF_FBW7_1	419:426	Mutation blocking phosphorylation signal	0.5556
p.R631W	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	VSSSS	DEG_SPOP_SBC_1	630:634	Mutation altering degron motif	0.8634
p.R1284Q	HCC2998	large intestine	COSMIC	DSGKFS	DEG_SCF_TRCP1_1	1283:1288	Mutation altering degron motif	0.7329
p.S410Y	SNU-407	large intestine	COSMIC	VPTTPTSS	DEG_SCF_FBW7_1	419:426	Mutation rewiring degron network	0.0833
p.S410Y	NOMO-1	haematopoietic and lymphoid tissue	COSMIC	VPTTPTSS	DEG_SCF_FBW7_1	419:426	Mutation rewiring degron network	0.0833
p.S410Y	HSC-3	upper aerodigestive tract	COSMIC	VPTTPTSS	DEG_SCF_FBW7_1	419:426	Mutation rewiring degron network	0.0833
p.S410Y	OSC-20	upper aerodigestive tract	COSMIC	VPTTPTSS	DEG_SCF_FBW7_1	419:426	Mutation rewiring degron network	0.0833
p.R418Q	SNU-81	large intestine	COSMIC	VPTTPTSS	DEG_SCF_FBW7_1	419:426	Mutation rewiring degron network	0.3056
p.K1296N	HT-115	large intestine	COSMIC	DSGKFS	DEG_SCF_TRCP1_1	1283:1288	Mutation blocking phosphorylation signal	0.5556
p.T422P	NCI-H1876	lung	COSMIC	VPTTPTSS	DEG_SCF_FBW7_1	419:426	Mutation altering degron motif	0.7031
p.R1284W	DU-145	prostate	COSMIC	DSGKFS	DEG_SCF_TRCP1_1	1283:1288	Mutation altering degron motif	0.8634
p.E630Q	HCC1143	breast	COSMIC	VSSSS	DEG_SPOP_SBC_1	630:634	Mutation altering degron motif	0.6744
p.K1279N	HT-115	large intestine	COSMIC	DSGKFS	DEG_SCF_TRCP1_1	1283:1288	Mutation substituting flanking lysine	0.3333

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FHOD3

UniProt ID: Q2V2M9

Entrez ID: 80206

Protein name: FH1/FH2 domain-containing protein 3 (Formactin-2) (Formin homolog overexpressed in spleen 2) (hFHOS2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FHOD3 in