DegronMD

Uniprot ID: Q2V2M9

Source protein: FH1/FH2 domain-containing protein 3

Source gene: FHOD3

Class: DEG_SCF_FBW7_1

Location: 419:426

E3 ligase: FBXW7

DEGRON score: 0.97

ASA_SCORE: 86.5375

COIL: 0.9468

CONS_SCORE: 0.311

DSS_SCORE: 0.7272

HELIX: 0.0212

FCONS_SCORE: 0.9821

RIG_SCORE: 0.5437

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S426F	TCGA-3N-A9WB	SKCM	TCGA	VPTTPTSS	DEG_SCF_FBW7_1	0.9093
p.P413S	TCGA-BG-A0M4	UCEC	TCGA	VPTTPTSS	DEG_SCF_FBW7_1	0.1667
p.V427I	TCGA-BS-A0V4	UCEC	TCGA	VPTTPTSS	DEG_SCF_FBW7_1	0.3056
p.V431F	DO228976	LICA	ICGC	VPTTPTSS	DEG_SCF_FBW7_1	0.1944
p.C424F	DO229027	LICA	ICGC	VPTTPTSS	DEG_SCF_FBW7_1	0.7108
p.E411D	DO227603	ORCA	ICGC	VPTTPTSS	DEG_SCF_FBW7_1	0.5556
p.S423F	DO47268	SKCM	ICGC	VPTTPTSS	DEG_SCF_FBW7_1	0.7982
p.A433P	DO229272	THCA	ICGC	VPTTPTSS	DEG_SCF_FBW7_1	0.1389
p.Q425H	DO229218	THCA	ICGC	VPTTPTSS	DEG_SCF_FBW7_1	0.7582
p.A433T	DO229221	THCA	ICGC	VPTTPTSS	DEG_SCF_FBW7_1	0.1389
p.P430R	HCE-4	oesophagus	COSMIC	VPTTPTSS	DEG_SCF_FBW7_1	0.2222
p.S411A	CCK-81	large_intestine	COSMIC	VPTTPTSS	DEG_SCF_FBW7_1	0.5556
p.S410Y	SNU-407	large_intestine	COSMIC	VPTTPTSS	DEG_SCF_FBW7_1	0.0833
p.S410Y	NOMO-1	haematopoietic_and_lymphoid_tissue	COSMIC	VPTTPTSS	DEG_SCF_FBW7_1	0.0833
p.S410Y	HSC-3	upper_aerodigestive_tract	COSMIC	VPTTPTSS	DEG_SCF_FBW7_1	0.0833
p.S410Y	OSC-20	upper_aerodigestive_tract	COSMIC	VPTTPTSS	DEG_SCF_FBW7_1	0.0833
p.R418Q	SNU-81	large_intestine	COSMIC	VPTTPTSS	DEG_SCF_FBW7_1	0.3056
p.T422P	NCI-H1876	lung	COSMIC	VPTTPTSS	DEG_SCF_FBW7_1	0.7031

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q2V2M9	FH1/FH2 domain-containing protein 3	DEG_SCF_FBW7_1	419:426	VPTTPTSS	FBXW7	0.97	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons