DegronMD

Uniprot ID: P09884

Source protein: DNA polymerase alpha catalytic subunit

Source gene: POLA1

Class: DEG_SCF_TRCP1_1

Location: 288:293

E3 ligase: BTRC

DEGRON score: 0.9912

ASA_SCORE: 80.8833

COIL: 0.9042

CONS_SCORE: 0.2632

DSS_SCORE: 0.4632

HELIX: 0.0562

FCONS_SCORE: 0.9405

RIG_SCORE: 0.6614

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E288G	SIDM01043	Other Sarcomas	GDSC	DSGKGT	DEG_SCF_TRCP1_1	0.7199
p.E288G	ESS-1	endometrium	COSMIC	DSGKGT	DEG_SCF_TRCP1_1	0.7199
p.A287V	ACH-000612	Lymphoma	CCLE	DSGKGT	DEG_SCF_TRCP1_1	0.3056
p.E282G	ACH-000913	Endometrial/Uterine Cancer	CCLE	DSGKGT	DEG_SCF_TRCP1_1	0.1667
p.E282G	ESS-1	endometrium	COSMIC	DSGKGT	DEG_SCF_TRCP1_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P09884	DNA polymerase alpha catalytic subunit	DEG_SCF_TRCP1_1	288:293	DSGKGT	BTRC	0.9912	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons