DegronMD - P09884(POLA1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A21S	TCGA-53-7626	LUAD	TCGA	DSGSFVS	DEG_SCF_TRCP1_1	12:18	Mutation rewiring degron network	0.25
p.A21S	DO23774	LUAD	ICGC	DSGSFVS	DEG_SCF_TRCP1_1	12:18	Mutation rewiring degron network	0.25
p.D8N	TCGA-AX-A2HC	UCEC	TCGA	DSGSFVS	DEG_SCF_TRCP1_1	12:18	Mutation substituting flanking lysine	0.3333
p.D8N	DO41572	UCEC	ICGC	DSGSFVS	DEG_SCF_TRCP1_1	12:18	Mutation substituting flanking lysine	0.3333
p.R20G	TCGA-BH-A0B6	BRCA	TCGA	DSGSFVS	DEG_SCF_TRCP1_1	12:18	Mutation rewiring degron network	0.2778
p.R20G	DO2641	BRCA	ICGC	DSGSFVS	DEG_SCF_TRCP1_1	12:18	Mutation rewiring degron network	0.2778
p.R20G	DO48244	ESCA	ICGC	DSGSFVS	DEG_SCF_TRCP1_1	12:18	Mutation rewiring degron network	0.2778
p.K25N	TCGA-F5-6814	READ	TCGA	DSGSFVS	DEG_SCF_TRCP1_1	12:18	Mutation substituting flanking lysine	0.25
p.K25N	DO36556	READ	ICGC	DSGSFVS	DEG_SCF_TRCP1_1	12:18	Mutation substituting flanking lysine	0.25
p.S18C	TCGA-IR-A3LK	CESC	TCGA	DSGSFVS	DEG_SCF_TRCP1_1	12:18	Mutation altering degron motif	0.8652
p.S18C	DO44299	CESC	ICGC	DSGSFVS	DEG_SCF_TRCP1_1	12:18	Mutation altering degron motif	0.8652
p.S13L	DO222726	BTCA	ICGC	DSGSFVS	DEG_SCF_TRCP1_1	12:18	Mutation altering degron motif	0.8778
p.D12Y	DO229009	LICA	ICGC	DSGSFVS	DEG_SCF_TRCP1_1	12:18	Mutation altering degron motif	0.7325
p.A13V	DO41999	UCEC	ICGC	DSGSFVS	DEG_SCF_TRCP1_1	12:18	Mutation altering degron motif	0.6936
p.A13V	SIDM00373	Endometrial Carcinoma	GDSC	DSGSFVS	DEG_SCF_TRCP1_1	12:18	Mutation altering degron motif	0.6936
p.E288G	SIDM01043	Other Sarcomas	GDSC	DSGKGT	DEG_SCF_TRCP1_1	288:293	Mutation altering degron motif	0.7199
p.E288G	ESS-1	endometrium	COSMIC	DSGKGT	DEG_SCF_TRCP1_1	288:293	Mutation altering degron motif	0.7199
p.A287V	ACH-000612	Lymphoma	CCLE	DSGKGT	DEG_SCF_TRCP1_1	288:293	Mutation rewiring degron network	0.3056
p.K28R	ACH-000870	Lung Cancer	CCLE	DSGSFVS	DEG_SCF_TRCP1_1	12:18	Mutation substituting flanking lysine	0.1667
p.E282G	ACH-000913	Endometrial/Uterine Cancer	CCLE	DSGKGT	DEG_SCF_TRCP1_1	288:293	Mutation rewiring degron network	0.1667
p.E282G	ESS-1	endometrium	COSMIC	DSGKGT	DEG_SCF_TRCP1_1	288:293	Mutation rewiring degron network	0.1667

Kaplan plot for POLA1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

POLA1

UniProt ID: P09884

Entrez ID: 5422

Protein name: DNA polymerase alpha catalytic subunit (EC 2.7.7.7) (DNA polymerase alpha catalytic subunit p180)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for POLA1 in