DegronMD

Uniprot ID: P09884

Source protein: DNA polymerase alpha catalytic subunit

Source gene: POLA1

Class: DEG_SCF_TRCP1_1

Location: 12:18

E3 ligase: BTRC

DEGRON score: 0.9975

ASA_SCORE: 84.4571

COIL: 0.8104

CONS_SCORE: 0.267

DSS_SCORE: 0.5908

HELIX: 0.1633

FCONS_SCORE: 1.0239

RIG_SCORE: 0.6243

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A21S	TCGA-53-7626	LUAD	TCGA	DSGSFVS	DEG_SCF_TRCP1_1	0.25
p.A21S	DO23774	LUAD	ICGC	DSGSFVS	DEG_SCF_TRCP1_1	0.25
p.D8N	TCGA-AX-A2HC	UCEC	TCGA	DSGSFVS	DEG_SCF_TRCP1_1	0.3333
p.D8N	DO41572	UCEC	ICGC	DSGSFVS	DEG_SCF_TRCP1_1	0.3333
p.R20G	TCGA-BH-A0B6	BRCA	TCGA	DSGSFVS	DEG_SCF_TRCP1_1	0.2778
p.R20G	DO2641	BRCA	ICGC	DSGSFVS	DEG_SCF_TRCP1_1	0.2778
p.R20G	DO48244	ESCA	ICGC	DSGSFVS	DEG_SCF_TRCP1_1	0.2778
p.K25N	TCGA-F5-6814	READ	TCGA	DSGSFVS	DEG_SCF_TRCP1_1	0.25
p.K25N	DO36556	READ	ICGC	DSGSFVS	DEG_SCF_TRCP1_1	0.25
p.S18C	TCGA-IR-A3LK	CESC	TCGA	DSGSFVS	DEG_SCF_TRCP1_1	0.8652
p.S18C	DO44299	CESC	ICGC	DSGSFVS	DEG_SCF_TRCP1_1	0.8652
p.S13L	DO222726	BTCA	ICGC	DSGSFVS	DEG_SCF_TRCP1_1	0.8778
p.D12Y	DO229009	LICA	ICGC	DSGSFVS	DEG_SCF_TRCP1_1	0.7325
p.A13V	DO41999	UCEC	ICGC	DSGSFVS	DEG_SCF_TRCP1_1	0.6936
p.A13V	SIDM00373	Endometrial Carcinoma	GDSC	DSGSFVS	DEG_SCF_TRCP1_1	0.6936
p.K28R	ACH-000870	Lung Cancer	CCLE	DSGSFVS	DEG_SCF_TRCP1_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P09884	DNA polymerase alpha catalytic subunit	DEG_SCF_TRCP1_1	12:18	DSGSFVS	BTRC	0.9975	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons