DegronMD

Uniprot ID: O94818

Source protein: Nucleolar protein 4

Source gene: NOL4

Class: DEG_SCF_TRCP1_1

Location: 362:368

E3 ligase: BTRC

DEGRON score: 0.9776

ASA_SCORE: 80.2286

COIL: 0.8143

CONS_SCORE: 0.4446

DSS_SCORE: 0.6381

HELIX: 0.129

FCONS_SCORE: 0.9263

RIG_SCORE: 0.5645

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G372A	TCGA-49-4507	LUAD	TCGA	DSGKNES	DEG_SCF_TRCP1_1	0.2222
p.G372A	DO25727	LUAD	ICGC	DSGKNES	DEG_SCF_TRCP1_1	0.2222
p.E367D	TCGA-58-A46N	LUSC	TCGA	DSGKNES	DEG_SCF_TRCP1_1	0.5647
p.E367D	DO45460	LUSC	ICGC	DSGKNES	DEG_SCF_TRCP1_1	0.5647
p.P354H	TCGA-78-8640	LUAD	TCGA	DSGKNES	DEG_SCF_TRCP1_1	0.1111
p.P354H	DO45340	LUAD	ICGC	DSGKNES	DEG_SCF_TRCP1_1	0.1111
p.S359F	TCGA-A5-A2K5	UCEC	TCGA	DSGKNES	DEG_SCF_TRCP1_1	0.25
p.S359F	DO41379	UCEC	ICGC	DSGKNES	DEG_SCF_TRCP1_1	0.25
p.L376I	TCGA-AP-A059	UCEC	TCGA	DSGKNES	DEG_SCF_TRCP1_1	0.1111
p.L376I	DO41361	UCEC	ICGC	DSGKNES	DEG_SCF_TRCP1_1	0.1111
p.S353Y	TCGA-AX-A1C8	UCEC	TCGA	DSGKNES	DEG_SCF_TRCP1_1	0.5278
p.S353Y	TCGA-B5-A1MR	UCEC	TCGA	DSGKNES	DEG_SCF_TRCP1_1	0.5278
p.S353Y	DO43338	UCEC	ICGC	DSGKNES	DEG_SCF_TRCP1_1	0.5278
p.S353Y	DO41758	UCEC	ICGC	DSGKNES	DEG_SCF_TRCP1_1	0.5278
p.P354A	TCGA-CV-A45W	HNSC	TCGA	DSGKNES	DEG_SCF_TRCP1_1	0.1111
p.P354A	DO52060	HNSC	ICGC	DSGKNES	DEG_SCF_TRCP1_1	0.1111
p.P354S	TCGA-EE-A29E	SKCM	TCGA	DSGKNES	DEG_SCF_TRCP1_1	0.1111
p.P354S	DO37831	SKCM	ICGC	DSGKNES	DEG_SCF_TRCP1_1	0.1111
p.G372E	TCGA-EE-A2A1	SKCM	TCGA	DSGKNES	DEG_SCF_TRCP1_1	0.2222
p.G372E	TCGA-FW-A3R5	SKCM	TCGA	DSGKNES	DEG_SCF_TRCP1_1	0.2222
p.G372E	DO37406	SKCM	ICGC	DSGKNES	DEG_SCF_TRCP1_1	0.2222
p.G372E	DO38045	SKCM	ICGC	DSGKNES	DEG_SCF_TRCP1_1	0.2222
p.V369I	TCGA-FG-8186	LGG	TCGA	DSGKNES	DEG_SCF_TRCP1_1	0.3056
p.V369I	DO22113	LGG	ICGC	DSGKNES	DEG_SCF_TRCP1_1	0.3056
p.S368T	TCGA-HZ-8002	PAAD	TCGA	DSGKNES	DEG_SCF_TRCP1_1	0.6005
p.S368T	DO32757	PAAD	ICGC	DSGKNES	DEG_SCF_TRCP1_1	0.6005
p.D362G	TCGA-IN-A6RO	STAD	TCGA	DSGKNES	DEG_SCF_TRCP1_1	0.7198
p.D362G	DO51740	STAD	ICGC	DSGKNES	DEG_SCF_TRCP1_1	0.7198
p.S357T	DO224547	BRCA	ICGC	DSGKNES	DEG_SCF_TRCP1_1	0.1944
p.S357T	DO1001	BRCA	ICGC	DSGKNES	DEG_SCF_TRCP1_1	0.1944
p.K365Q	DO222535	ESCA	ICGC	DSGKNES	DEG_SCF_TRCP1_1	0.5833
p.Y361N	DO228791	GACA	ICGC	DSGKNES	DEG_SCF_TRCP1_1	0.75
p.S363Y	SIDM01162	Kidney Carcinoma	GDSC	DSGKNES	DEG_SCF_TRCP1_1	0.8231
p.S363Y	SW156	kidney	COSMIC	DSGKNES	DEG_SCF_TRCP1_1	0.8231
p.R371Q	SIDM00905	Cervical Carcinoma	GDSC	DSGKNES	DEG_SCF_TRCP1_1	0.25
p.R371Q	C-4-I	cervix	COSMIC	DSGKNES	DEG_SCF_TRCP1_1	0.25
p.D370G	SIDM00958	Chronic Myelogenous Leukemia	GDSC	DSGKNES	DEG_SCF_TRCP1_1	0.2778
p.D370G	ACH-000920	Leukemia	CCLE	DSGKNES	DEG_SCF_TRCP1_1	0.2778
p.D370G	CML-T1	haematopoietic_and_lymphoid_tissue	COSMIC	DSGKNES	DEG_SCF_TRCP1_1	0.2778
p.Q352L	ACH-000802	Bladder Cancer	CCLE	DSGKNES	DEG_SCF_TRCP1_1	0.1667
p.Q352L	BFTC-905	urinary_tract	COSMIC	DSGKNES	DEG_SCF_TRCP1_1	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSGKNES

Degron related mutations and impact score

Drug responses associated with NOL4 mutations

All proteins holding degron of DSGKNES

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94818	Nucleolar protein 4	DEG_SCF_TRCP1_1	362:368	DSGKNES	BTRC	0.9776	More...