DegronMD - O94818(NOL4)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R30H	TCGA-3M-AB47	STAD	TCGA	DSGKTKT	DEG_SCF_TRCP1_1	21:27	Mutation rewiring degron network	0.25
p.R30H	DO222327	STAD	ICGC	DSGKTKT	DEG_SCF_TRCP1_1	21:27	Mutation rewiring degron network	0.25
p.G372A	TCGA-49-4507	LUAD	TCGA	DSGKNES	DEG_SCF_TRCP1_1	362:368	Mutation rewiring degron network	0.2222
p.G372A	DO25727	LUAD	ICGC	DSGKNES	DEG_SCF_TRCP1_1	362:368	Mutation rewiring degron network	0.2222
p.E367D	TCGA-58-A46N	LUSC	TCGA	DSGKNES	DEG_SCF_TRCP1_1	362:368	Mutation altering degron motif	0.5647
p.E367D	DO45460	LUSC	ICGC	DSGKNES	DEG_SCF_TRCP1_1	362:368	Mutation altering degron motif	0.5647
p.P354H	TCGA-78-8640	LUAD	TCGA	DSGKNES	DEG_SCF_TRCP1_1	362:368	Mutation rewiring degron network	0.1111
p.P354H	DO45340	LUAD	ICGC	DSGKNES	DEG_SCF_TRCP1_1	362:368	Mutation rewiring degron network	0.1111
p.S22L	TCGA-86-8278	LUAD	TCGA	DSGKTKT	DEG_SCF_TRCP1_1	21:27	Mutation altering degron motif	0.7667
p.S22L	DO26308	LUAD	ICGC	DSGKTKT	DEG_SCF_TRCP1_1	21:27	Mutation altering degron motif	0.7667
p.S359F	TCGA-A5-A2K5	UCEC	TCGA	DSGKNES	DEG_SCF_TRCP1_1	362:368	Mutation rewiring degron network	0.25
p.S359F	DO41379	UCEC	ICGC	DSGKNES	DEG_SCF_TRCP1_1	362:368	Mutation rewiring degron network	0.25
p.L376I	TCGA-AP-A059	UCEC	TCGA	DSGKNES	DEG_SCF_TRCP1_1	362:368	Mutation rewiring degron network	0.1111
p.L376I	DO41361	UCEC	ICGC	DSGKNES	DEG_SCF_TRCP1_1	362:368	Mutation rewiring degron network	0.1111
p.S353Y	TCGA-AX-A1C8	UCEC	TCGA	DSGKNES	DEG_SCF_TRCP1_1	362:368	Mutation blocking phosphorylation signal	0.5278
p.S353Y	TCGA-B5-A1MR	UCEC	TCGA	DSGKNES	DEG_SCF_TRCP1_1	362:368	Mutation blocking phosphorylation signal	0.5278
p.S353Y	DO43338	UCEC	ICGC	DSGKNES	DEG_SCF_TRCP1_1	362:368	Mutation blocking phosphorylation signal	0.5278
p.S353Y	DO41758	UCEC	ICGC	DSGKNES	DEG_SCF_TRCP1_1	362:368	Mutation blocking phosphorylation signal	0.5278
p.C15R	TCGA-BR-7851	STAD	TCGA	DSGKTKT	DEG_SCF_TRCP1_1	21:27	Mutation rewiring degron network	0.1667
p.C15R	DO38711	STAD	ICGC	DSGKTKT	DEG_SCF_TRCP1_1	21:27	Mutation rewiring degron network	0.1667
p.P354A	TCGA-CV-A45W	HNSC	TCGA	DSGKNES	DEG_SCF_TRCP1_1	362:368	Mutation rewiring degron network	0.1111
p.P354A	DO52060	HNSC	ICGC	DSGKNES	DEG_SCF_TRCP1_1	362:368	Mutation rewiring degron network	0.1111
p.T29I	TCGA-E7-A677	BLCA	TCGA	DSGKTKT	DEG_SCF_TRCP1_1	21:27	Mutation rewiring degron network	0.2778
p.T29I	DO44033	BLCA	ICGC	DSGKTKT	DEG_SCF_TRCP1_1	21:27	Mutation rewiring degron network	0.2778
p.P354S	TCGA-EE-A29E	SKCM	TCGA	DSGKNES	DEG_SCF_TRCP1_1	362:368	Mutation rewiring degron network	0.1111
p.P354S	DO37831	SKCM	ICGC	DSGKNES	DEG_SCF_TRCP1_1	362:368	Mutation rewiring degron network	0.1111
p.G372E	TCGA-EE-A2A1	SKCM	TCGA	DSGKNES	DEG_SCF_TRCP1_1	362:368	Mutation rewiring degron network	0.2222
p.G372E	TCGA-FW-A3R5	SKCM	TCGA	DSGKNES	DEG_SCF_TRCP1_1	362:368	Mutation rewiring degron network	0.2222
p.G372E	DO37406	SKCM	ICGC	DSGKNES	DEG_SCF_TRCP1_1	362:368	Mutation rewiring degron network	0.2222
p.G372E	DO38045	SKCM	ICGC	DSGKNES	DEG_SCF_TRCP1_1	362:368	Mutation rewiring degron network	0.2222
p.V369I	TCGA-FG-8186	LGG	TCGA	DSGKNES	DEG_SCF_TRCP1_1	362:368	Mutation rewiring degron network	0.3056
p.V369I	DO22113	LGG	ICGC	DSGKNES	DEG_SCF_TRCP1_1	362:368	Mutation rewiring degron network	0.3056
p.E34K	TCGA-FR-A726	SKCM	TCGA	DSGKTKT	DEG_SCF_TRCP1_1	21:27	Mutation rewiring degron network	0.1389
p.E34K	DO48665	SKCM	ICGC	DSGKTKT	DEG_SCF_TRCP1_1	21:27	Mutation rewiring degron network	0.1389
p.E34K	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	DSGKTKT	DEG_SCF_TRCP1_1	21:27	Mutation rewiring degron network	0.1389
p.E34K	ACH-000980	Lung Cancer	CCLE	DSGKTKT	DEG_SCF_TRCP1_1	21:27	Mutation rewiring degron network	0.1389
p.E34K	NCI-H1155	lung	COSMIC	DSGKTKT	DEG_SCF_TRCP1_1	21:27	Mutation rewiring degron network	0.1389
p.S368T	TCGA-HZ-8002	PAAD	TCGA	DSGKNES	DEG_SCF_TRCP1_1	362:368	Mutation altering degron motif	0.6005
p.S368T	DO32757	PAAD	ICGC	DSGKNES	DEG_SCF_TRCP1_1	362:368	Mutation altering degron motif	0.6005
p.D362G	TCGA-IN-A6RO	STAD	TCGA	DSGKNES	DEG_SCF_TRCP1_1	362:368	Mutation altering degron motif	0.7198
p.D362G	DO51740	STAD	ICGC	DSGKNES	DEG_SCF_TRCP1_1	362:368	Mutation altering degron motif	0.7198
p.S357T	DO224547	BRCA	ICGC	DSGKNES	DEG_SCF_TRCP1_1	362:368	Mutation rewiring degron network	0.1944
p.S357T	DO1001	BRCA	ICGC	DSGKNES	DEG_SCF_TRCP1_1	362:368	Mutation rewiring degron network	0.1944
p.K365Q	DO222535	ESCA	ICGC	DSGKNES	DEG_SCF_TRCP1_1	362:368	Mutation altering degron motif	0.5833
p.Y361N	DO228791	GACA	ICGC	DSGKNES	DEG_SCF_TRCP1_1	362:368	Mutation blocking phosphorylation signal	0.75
p.T27K	DO228971	LICA	ICGC	DSGKTKT	DEG_SCF_TRCP1_1	21:27	Mutation altering degron motif	0.7306
p.T14K	DO229022	LICA	ICGC	DSGKTKT	DEG_SCF_TRCP1_1	21:27	Mutation rewiring degron network	0.1389
p.T29N	DO229045	LICA	ICGC	DSGKTKT	DEG_SCF_TRCP1_1	21:27	Mutation rewiring degron network	0.2778
p.R17S	DO50707	ORCA	ICGC	DSGKTKT	DEG_SCF_TRCP1_1	21:27	Mutation rewiring degron network	0.2222
p.I36T	SIDM01259	B-Lymphoblastic Leukemia	GDSC	DSGKTKT	DEG_SCF_TRCP1_1	21:27	Mutation rewiring degron network	0.0833
p.I36T	ACH-001669	Leukemia	CCLE	DSGKTKT	DEG_SCF_TRCP1_1	21:27	Mutation rewiring degron network	0.0833
p.I36T	ACH-002238	Leukemia	CCLE	DSGKTKT	DEG_SCF_TRCP1_1	21:27	Mutation rewiring degron network	0.0833
p.I36T	GR-ST	haematopoietic and lymphoid tissue	COSMIC	DSGKTKT	DEG_SCF_TRCP1_1	21:27	Mutation rewiring degron network	0.0833
p.S363Y	SIDM01162	Kidney Carcinoma	GDSC	DSGKNES	DEG_SCF_TRCP1_1	362:368	Mutation altering degron motif	0.8231
p.S363Y	SW156	kidney	COSMIC	DSGKNES	DEG_SCF_TRCP1_1	362:368	Mutation altering degron motif	0.8231
p.R371Q	SIDM00905	Cervical Carcinoma	GDSC	DSGKNES	DEG_SCF_TRCP1_1	362:368	Mutation rewiring degron network	0.25
p.R371Q	C-4-I	cervix	COSMIC	DSGKNES	DEG_SCF_TRCP1_1	362:368	Mutation rewiring degron network	0.25
p.D370G	SIDM00958	Chronic Myelogenous Leukemia	GDSC	DSGKNES	DEG_SCF_TRCP1_1	362:368	Mutation rewiring degron network	0.2778
p.D370G	ACH-000920	Leukemia	CCLE	DSGKNES	DEG_SCF_TRCP1_1	362:368	Mutation rewiring degron network	0.2778
p.D370G	CML-T1	haematopoietic and lymphoid tissue	COSMIC	DSGKNES	DEG_SCF_TRCP1_1	362:368	Mutation rewiring degron network	0.2778
p.N20K	ACH-000158	Lymphoma	CCLE	DSGKTKT	DEG_SCF_TRCP1_1	21:27	Mutation rewiring degron network	0.3056
p.Q352L	ACH-000802	Bladder Cancer	CCLE	DSGKNES	DEG_SCF_TRCP1_1	362:368	Mutation substituting flanking lysine	0.1667
p.Q352L	BFTC-905	urinary tract	COSMIC	DSGKNES	DEG_SCF_TRCP1_1	362:368	Mutation substituting flanking lysine	0.1667
p.S32W	ACH-000943	Colon/Colorectal Cancer	CCLE	DSGKTKT	DEG_SCF_TRCP1_1	21:27	Mutation substituting flanking lysine	0.3056
p.S32W	RKO	large intestine	COSMIC	DSGKTKT	DEG_SCF_TRCP1_1	21:27	Mutation substituting flanking lysine	0.3056
p.L21P	ACH-000962	Ovarian Cancer	CCLE	DSGKTKT	DEG_SCF_TRCP1_1	21:27	Mutation altering degron motif	0.7582
p.L21P	ACH-001145	Ovarian Cancer	CCLE	DSGKTKT	DEG_SCF_TRCP1_1	21:27	Mutation altering degron motif	0.7582
p.L21P	OC-314	ovary	COSMIC	DSGKTKT	DEG_SCF_TRCP1_1	21:27	Mutation altering degron motif	0.7582
p.T31P	ACH-000991	Colon/Colorectal Cancer	CCLE	DSGKTKT	DEG_SCF_TRCP1_1	21:27	Mutation substituting flanking lysine	0.3333
p.T31P	SNU-81	large intestine	COSMIC	DSGKTKT	DEG_SCF_TRCP1_1	21:27	Mutation substituting flanking lysine	0.3333
p.G20R	ACH-001568	Skin Cancer	CCLE	DSGKTKT	DEG_SCF_TRCP1_1	21:27	Mutation rewiring degron network	0.3056
p.I37N	NCI-H1770	lung	COSMIC	DSGKTKT	DEG_SCF_TRCP1_1	21:27	Mutation rewiring degron network	0.0556
p.I37S	SNU-1040	large intestine	COSMIC	DSGKTKT	DEG_SCF_TRCP1_1	21:27	Mutation rewiring degron network	0.0556
p.R27W	CAL-51	breast	COSMIC	DSGKTKT	DEG_SCF_TRCP1_1	21:27	Mutation altering degron motif	0.8634

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NOL4

UniProt ID: O94818

Entrez ID: 8715

Protein name: Nucleolar protein 4 (Nucleolar-localized protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NOL4 in