DegronMD

Uniprot ID: O94818

Source protein: Nucleolar protein 4

Source gene: NOL4

Class: DEG_SCF_TRCP1_1

Location: 21:27

E3 ligase: BTRC

DEGRON score: 0.5487

ASA_SCORE: 80.3857

COIL: 0.7039

CONS_SCORE: 0.4952

DSS_SCORE: 0.3015

HELIX: 0.1906

FCONS_SCORE: 0.9534

RIG_SCORE: 0.7293

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R30H	TCGA-3M-AB47	STAD	TCGA	DSGKTKT	DEG_SCF_TRCP1_1	0.25
p.R30H	DO222327	STAD	ICGC	DSGKTKT	DEG_SCF_TRCP1_1	0.25
p.S22L	TCGA-86-8278	LUAD	TCGA	DSGKTKT	DEG_SCF_TRCP1_1	0.7667
p.S22L	DO26308	LUAD	ICGC	DSGKTKT	DEG_SCF_TRCP1_1	0.7667
p.C15R	TCGA-BR-7851	STAD	TCGA	DSGKTKT	DEG_SCF_TRCP1_1	0.1667
p.C15R	DO38711	STAD	ICGC	DSGKTKT	DEG_SCF_TRCP1_1	0.1667
p.T29I	TCGA-E7-A677	BLCA	TCGA	DSGKTKT	DEG_SCF_TRCP1_1	0.2778
p.T29I	DO44033	BLCA	ICGC	DSGKTKT	DEG_SCF_TRCP1_1	0.2778
p.E34K	TCGA-FR-A726	SKCM	TCGA	DSGKTKT	DEG_SCF_TRCP1_1	0.1389
p.E34K	DO48665	SKCM	ICGC	DSGKTKT	DEG_SCF_TRCP1_1	0.1389
p.E34K	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	DSGKTKT	DEG_SCF_TRCP1_1	0.1389
p.E34K	ACH-000980	Lung Cancer	CCLE	DSGKTKT	DEG_SCF_TRCP1_1	0.1389
p.E34K	NCI-H1155	lung	COSMIC	DSGKTKT	DEG_SCF_TRCP1_1	0.1389
p.T27K	DO228971	LICA	ICGC	DSGKTKT	DEG_SCF_TRCP1_1	0.7306
p.T14K	DO229022	LICA	ICGC	DSGKTKT	DEG_SCF_TRCP1_1	0.1389
p.T29N	DO229045	LICA	ICGC	DSGKTKT	DEG_SCF_TRCP1_1	0.2778
p.R17S	DO50707	ORCA	ICGC	DSGKTKT	DEG_SCF_TRCP1_1	0.2222
p.I36T	SIDM01259	B-Lymphoblastic Leukemia	GDSC	DSGKTKT	DEG_SCF_TRCP1_1	0.0833
p.I36T	ACH-001669	Leukemia	CCLE	DSGKTKT	DEG_SCF_TRCP1_1	0.0833
p.I36T	ACH-002238	Leukemia	CCLE	DSGKTKT	DEG_SCF_TRCP1_1	0.0833
p.I36T	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	DSGKTKT	DEG_SCF_TRCP1_1	0.0833
p.N20K	ACH-000158	Lymphoma	CCLE	DSGKTKT	DEG_SCF_TRCP1_1	0.3056
p.S32W	ACH-000943	Colon/Colorectal Cancer	CCLE	DSGKTKT	DEG_SCF_TRCP1_1	0.3056
p.S32W	RKO	large_intestine	COSMIC	DSGKTKT	DEG_SCF_TRCP1_1	0.3056
p.L21P	ACH-000962	Ovarian Cancer	CCLE	DSGKTKT	DEG_SCF_TRCP1_1	0.7582
p.L21P	ACH-001145	Ovarian Cancer	CCLE	DSGKTKT	DEG_SCF_TRCP1_1	0.7582
p.L21P	OC-314	ovary	COSMIC	DSGKTKT	DEG_SCF_TRCP1_1	0.7582
p.T31P	ACH-000991	Colon/Colorectal Cancer	CCLE	DSGKTKT	DEG_SCF_TRCP1_1	0.3333
p.T31P	SNU-81	large_intestine	COSMIC	DSGKTKT	DEG_SCF_TRCP1_1	0.3333
p.G20R	ACH-001568	Skin Cancer	CCLE	DSGKTKT	DEG_SCF_TRCP1_1	0.3056
p.I37N	NCI-H1770	lung	COSMIC	DSGKTKT	DEG_SCF_TRCP1_1	0.0556
p.I37S	SNU-1040	large_intestine	COSMIC	DSGKTKT	DEG_SCF_TRCP1_1	0.0556
p.R27W	CAL-51	breast	COSMIC	DSGKTKT	DEG_SCF_TRCP1_1	0.8634

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSGKTKT

Degron related mutations and impact score

Drug responses associated with NOL4 mutations

All proteins holding degron of DSGKTKT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94818	Nucleolar protein 4	DEG_SCF_TRCP1_1	21:27	DSGKTKT	BTRC	0.5487	More...