DegronMD

Uniprot ID: Q6P9F7

Source protein: Volume-regulated anion channel subunit LRRC8B

Source gene: LRRC8B

Class: DEG_SCF_TRCP1_1

Location: 200:205

E3 ligase: BTRC

DEGRON score: 0.8115

ASA_SCORE: 90.4333

COIL: 0.9108

CONS_SCORE: 0.5054

DSS_SCORE: 0.5759

HELIX: 0.0518

FCONS_SCORE: 1.0725

RIG_SCORE: 0.6425

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S196L	TCGA-C5-A1BE	CESC	TCGA	DSGKQS	DEG_SCF_TRCP1_1	0.2222
p.S196L	DO49006	CESC	ICGC	DSGKQS	DEG_SCF_TRCP1_1	0.2222
p.S191L	TCGA-W3-A828	SKCM	TCGA	DSGKQS	DEG_SCF_TRCP1_1	0.0833
p.S191L	DO51273	SKCM	ICGC	DSGKQS	DEG_SCF_TRCP1_1	0.0833
p.I199T	TCGA-ZG-A9NI	PRAD	TCGA	DSGKQS	DEG_SCF_TRCP1_1	0.3056
p.I199T	DO219448	PRAD	ICGC	DSGKQS	DEG_SCF_TRCP1_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6P9F7	Volume-regulated anion channel subunit LRRC8B	DEG_SCF_TRCP1_1	200:205	DSGKQS	BTRC	0.8115	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons