DegronMD

Uniprot ID: Q9NXR1

Source protein: Nuclear distribution protein nudE homolog 1

Source gene: NDE1

Class: DEG_SCF_TRCP1_1

Location: 3:9

E3 ligase: BTRC

DEGRON score: 0.9618

ASA_SCORE: 84.8714

COIL: 0.946

CONS_SCORE: 0.5962

DSS_SCORE: 0.7884

HELIX: 0.0289

FCONS_SCORE: 0.8963

RIG_SCORE: 0.662

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S10C	TCGA-CF-A47V	BLCA	TCGA	DSGKTFS	DEG_SCF_TRCP1_1	0.75
p.S10C	DO44053	BLCA	ICGC	DSGKTFS	DEG_SCF_TRCP1_1	0.75
p.G5R	TCGA-D5-6531	COAD	TCGA	DSGKTFS	DEG_SCF_TRCP1_1	0.7568
p.G5R	DO7983	COAD	ICGC	DSGKTFS	DEG_SCF_TRCP1_1	0.7568
p.S10F	TCGA-EE-A20C	SKCM	TCGA	DSGKTFS	DEG_SCF_TRCP1_1	0.75
p.S10F	DO222775	MELA	ICGC	DSGKTFS	DEG_SCF_TRCP1_1	0.75
p.S10F	DO47665	SKCM	ICGC	DSGKTFS	DEG_SCF_TRCP1_1	0.75
p.K6N	TCGA-F7-A622	HNSC	TCGA	DSGKTFS	DEG_SCF_TRCP1_1	0.5806
p.K6N	DO49039	HNSC	ICGC	DSGKTFS	DEG_SCF_TRCP1_1	0.5806
p.E11K	TCGA-GC-A3YS	BLCA	TCGA	DSGKTFS	DEG_SCF_TRCP1_1	0.2778
p.E11K	DO850	BLCA	ICGC	DSGKTFS	DEG_SCF_TRCP1_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NXR1	Nuclear distribution protein nudE homolog 1	DEG_SCF_TRCP1_1	3:9	DSGKTFS	BTRC	0.9618	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons