DegronMD - Q9NXR1(NDE1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R201G	TCGA-AB-2808	LAML	TCGA	PRTPMPS	DEG_SCF_FBW7_1	189:195	Mutation rewiring degron network	0.1667
p.R201G	DO21487	LAML	ICGC	PRTPMPS	DEG_SCF_FBW7_1	189:195	Mutation rewiring degron network	0.1667
p.E200K	TCGA-BR-4361	STAD	TCGA	PRTPMPS	DEG_SCF_FBW7_1	189:195	Mutation rewiring degron network	0.1944
p.E200K	TCGA-FD-A6TA	BLCA	TCGA	PRTPMPS	DEG_SCF_FBW7_1	189:195	Mutation rewiring degron network	0.1944
p.E200K	DO49753	BLCA	ICGC	PRTPMPS	DEG_SCF_FBW7_1	189:195	Mutation rewiring degron network	0.1944
p.E200K	DO38887	STAD	ICGC	PRTPMPS	DEG_SCF_FBW7_1	189:195	Mutation rewiring degron network	0.1944
p.S10C	TCGA-CF-A47V	BLCA	TCGA	DSGKTFS	DEG_SCF_TRCP1_1	3:9	Mutation blocking phosphorylation signal	0.75
p.S10C	DO44053	BLCA	ICGC	DSGKTFS	DEG_SCF_TRCP1_1	3:9	Mutation blocking phosphorylation signal	0.75
p.G5R	TCGA-D5-6531	COAD	TCGA	DSGKTFS	DEG_SCF_TRCP1_1	3:9	Mutation altering degron motif	0.7568
p.G5R	DO7983	COAD	ICGC	DSGKTFS	DEG_SCF_TRCP1_1	3:9	Mutation altering degron motif	0.7568
p.S10F	TCGA-EE-A20C	SKCM	TCGA	DSGKTFS	DEG_SCF_TRCP1_1	3:9	Mutation blocking phosphorylation signal	0.75
p.S10F	DO222775	MELA	ICGC	DSGKTFS	DEG_SCF_TRCP1_1	3:9	Mutation blocking phosphorylation signal	0.75
p.S10F	DO47665	SKCM	ICGC	DSGKTFS	DEG_SCF_TRCP1_1	3:9	Mutation blocking phosphorylation signal	0.75
p.R298T	TCGA-EX-A3L1	CESC	TCGA	PSSTS	DEG_SPOP_SBC_1	305:309	Mutation rewiring degron network	0.1389
p.R298T	DO6335	CESC	ICGC	PSSTS	DEG_SPOP_SBC_1	305:309	Mutation rewiring degron network	0.1389
p.K6N	TCGA-F7-A622	HNSC	TCGA	DSGKTFS	DEG_SCF_TRCP1_1	3:9	Mutation altering degron motif	0.5806
p.K6N	DO49039	HNSC	ICGC	DSGKTFS	DEG_SCF_TRCP1_1	3:9	Mutation altering degron motif	0.5806
p.E11K	TCGA-GC-A3YS	BLCA	TCGA	DSGKTFS	DEG_SCF_TRCP1_1	3:9	Mutation rewiring degron network	0.2778
p.E11K	DO850	BLCA	ICGC	DSGKTFS	DEG_SCF_TRCP1_1	3:9	Mutation rewiring degron network	0.2778
p.P192H	TCGA-W3-AA1Q	SKCM	TCGA	PRTPMPS	DEG_SCF_FBW7_1	189:195	Mutation altering degron motif	0.7694
p.P192H	DO219487	SKCM	ICGC	PRTPMPS	DEG_SCF_FBW7_1	189:195	Mutation altering degron motif	0.7694
p.D299H	TCGA-ZF-AA4V	BLCA	TCGA	PSSTS	DEG_SPOP_SBC_1	305:309	Mutation rewiring degron network	0.1667
p.D299H	DO219087	BLCA	ICGC	PSSTS	DEG_SPOP_SBC_1	305:309	Mutation rewiring degron network	0.1667
p.V182M	DO228696	EOPC	ICGC	PRTPMPS	DEG_SCF_FBW7_1	189:195	Mutation rewiring degron network	0.1389
p.V182M	DO27885	ORCA	ICGC	PRTPMPS	DEG_SCF_FBW7_1	189:195	Mutation rewiring degron network	0.1389
p.S307R	SIDM00286	Neuroblastoma	GDSC	PSSTS	DEG_SPOP_SBC_1	305:309	Mutation altering degron motif	0.8538
p.S307R	CHP-126	autonomic ganglia	COSMIC	PSSTS	DEG_SPOP_SBC_1	305:309	Mutation altering degron motif	0.8538
p.K315E	SIDM00217	Colorectal Carcinoma	GDSC	PSSTS	DEG_SPOP_SBC_1	305:309	Mutation substituting flanking lysine	0.2778
p.K315E	ACH-000999	Colon/Colorectal Cancer	CCLE	PSSTS	DEG_SPOP_SBC_1	305:309	Mutation substituting flanking lysine	0.2778
p.K315E	SNU-1040	large intestine	COSMIC	PSSTS	DEG_SPOP_SBC_1	305:309	Mutation substituting flanking lysine	0.2778
p.D203A	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	PRTPMPS	DEG_SCF_FBW7_1	189:195	Mutation rewiring degron network	0.1111
p.D203A	ACH-000717	Esophageal Cancer	CCLE	PRTPMPS	DEG_SCF_FBW7_1	189:195	Mutation rewiring degron network	0.1111
p.D203A	COLO-680N	oesophagus	COSMIC	PRTPMPS	DEG_SCF_FBW7_1	189:195	Mutation rewiring degron network	0.1111
p.Q186E	SIDM00171	Colorectal Carcinoma	GDSC	PRTPMPS	DEG_SCF_FBW7_1	189:195	Mutation rewiring degron network	0.25
p.Q186E	ACH-000412	Colon/Colorectal Cancer	CCLE	PRTPMPS	DEG_SCF_FBW7_1	189:195	Mutation rewiring degron network	0.25

Kaplan plot for NDE1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NDE1

UniProt ID: Q9NXR1

Entrez ID: 54820

Protein name: Nuclear distribution protein nudE homolog 1 (NudE)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NDE1 in