DegronMD

Uniprot ID: Q9NXR1

Source protein: Nuclear distribution protein nudE homolog 1

Source gene: NDE1

Class: DEG_SCF_FBW7_1

Location: 189:195

E3 ligase: FBXW7

DEGRON score: 0.9775

ASA_SCORE: 107.0714

COIL: 0.9507

CONS_SCORE: 0.5959

DSS_SCORE: 0.7553

HELIX: 0.033

FCONS_SCORE: 0.9249

RIG_SCORE: 0.5998

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R201G	TCGA-AB-2808	LAML	TCGA	PRTPMPS	DEG_SCF_FBW7_1	0.1667
p.R201G	DO21487	LAML	ICGC	PRTPMPS	DEG_SCF_FBW7_1	0.1667
p.E200K	TCGA-BR-4361	STAD	TCGA	PRTPMPS	DEG_SCF_FBW7_1	0.1944
p.E200K	TCGA-FD-A6TA	BLCA	TCGA	PRTPMPS	DEG_SCF_FBW7_1	0.1944
p.E200K	DO49753	BLCA	ICGC	PRTPMPS	DEG_SCF_FBW7_1	0.1944
p.E200K	DO38887	STAD	ICGC	PRTPMPS	DEG_SCF_FBW7_1	0.1944
p.P192H	TCGA-W3-AA1Q	SKCM	TCGA	PRTPMPS	DEG_SCF_FBW7_1	0.7694
p.P192H	DO219487	SKCM	ICGC	PRTPMPS	DEG_SCF_FBW7_1	0.7694
p.V182M	DO228696	EOPC	ICGC	PRTPMPS	DEG_SCF_FBW7_1	0.1389
p.V182M	DO27885	ORCA	ICGC	PRTPMPS	DEG_SCF_FBW7_1	0.1389
p.D203A	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	PRTPMPS	DEG_SCF_FBW7_1	0.1111
p.D203A	ACH-000717	Esophageal Cancer	CCLE	PRTPMPS	DEG_SCF_FBW7_1	0.1111
p.D203A	COLO-680N	oesophagus	COSMIC	PRTPMPS	DEG_SCF_FBW7_1	0.1111
p.Q186E	SIDM00171	Colorectal Carcinoma	GDSC	PRTPMPS	DEG_SCF_FBW7_1	0.25
p.Q186E	ACH-000412	Colon/Colorectal Cancer	CCLE	PRTPMPS	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NXR1	Nuclear distribution protein nudE homolog 1	DEG_SCF_FBW7_1	189:195	PRTPMPS	FBXW7	0.9775	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons