DegronMD

Uniprot ID: Q9C0G0

Source protein: Zinc finger protein 407

Source gene: ZNF407

Class: DEG_SCF_TRCP1_1

Location: 510:515

E3 ligase: BTRC

DEGRON score: 0.9551

ASA_SCORE: 84.1333

COIL: 0.8108

CONS_SCORE: 0.439

DSS_SCORE: 0.6535

HELIX: 0.1212

FCONS_SCORE: 1.1188

RIG_SCORE: 0.6308

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G512R	DO230529	LUSC	ICGC	DSGLHS	DEG_SCF_TRCP1_1	0.7568
p.G512R	DO228529	MALY	ICGC	DSGLHS	DEG_SCF_TRCP1_1	0.7568
p.D510Y	TCGA-NJ-A55A	LUAD	TCGA	DSGLHS	DEG_SCF_TRCP1_1	0.7325
p.D510Y	DO218945	LUAD	ICGC	DSGLHS	DEG_SCF_TRCP1_1	0.7325
p.P508L	TCGA-FW-A3R5	SKCM	TCGA	DSGLHS	DEG_SCF_TRCP1_1	0.2778
p.P508L	DO37406	SKCM	ICGC	DSGLHS	DEG_SCF_TRCP1_1	0.2778
p.P508L	SIDM00257	Neuroblastoma	GDSC	DSGLHS	DEG_SCF_TRCP1_1	0.2778
p.R507C	TCGA-AJ-A3BG	UCEC	TCGA	DSGLHS	DEG_SCF_TRCP1_1	0.25
p.R507C	DO42633	UCEC	ICGC	DSGLHS	DEG_SCF_TRCP1_1	0.25
p.R507H	TCGA-HU-A4GQ	STAD	TCGA	DSGLHS	DEG_SCF_TRCP1_1	0.25
p.R507H	DO47767	STAD	ICGC	DSGLHS	DEG_SCF_TRCP1_1	0.25
p.R507H	SIDM00596	Endometrial Carcinoma	GDSC	DSGLHS	DEG_SCF_TRCP1_1	0.25
p.R507H	HEC-1	endometrium	COSMIC	DSGLHS	DEG_SCF_TRCP1_1	0.25
p.A521V	TCGA-CM-5861	COAD	TCGA	DSGLHS	DEG_SCF_TRCP1_1	0.1667
p.A521V	DO7918	COAD	ICGC	DSGLHS	DEG_SCF_TRCP1_1	0.1667

Showing 1 to 15 of 15 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9C0G0	Zinc finger protein 407	DEG_SCF_TRCP1_1	510:515	DSGLHS	BTRC	0.9551	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons