DegronMD - Q9C0G0(ZNF407)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q457K	TCGA-A3-A6NL	KIRC	TCGA	KRFNLLGIK	DEG_APCC_DBOX_1	442:450	Mutation rewiring degron network	0.1389
p.Q457K	DO50458	KIRC	ICGC	KRFNLLGIK	DEG_APCC_DBOX_1	442:450	Mutation rewiring degron network	0.1389
p.R507C	TCGA-AJ-A3BG	UCEC	TCGA	DSGLHS	DEG_SCF_TRCP1_1	510:515	Mutation rewiring degron network	0.25
p.R507C	DO42633	UCEC	ICGC	DSGLHS	DEG_SCF_TRCP1_1	510:515	Mutation rewiring degron network	0.25
p.A521V	TCGA-CM-5861	COAD	TCGA	DSGLHS	DEG_SCF_TRCP1_1	510:515	Mutation rewiring degron network	0.1667
p.A521V	DO7918	COAD	ICGC	DSGLHS	DEG_SCF_TRCP1_1	510:515	Mutation rewiring degron network	0.1667
p.P508L	TCGA-FW-A3R5	SKCM	TCGA	DSGLHS	DEG_SCF_TRCP1_1	510:515	Mutation rewiring degron network	0.2778
p.P508L	DO37406	SKCM	ICGC	DSGLHS	DEG_SCF_TRCP1_1	510:515	Mutation rewiring degron network	0.2778
p.P508L	SIDM00257	Neuroblastoma	GDSC	DSGLHS	DEG_SCF_TRCP1_1	510:515	Mutation rewiring degron network	0.2778
p.R507H	TCGA-HU-A4GQ	STAD	TCGA	DSGLHS	DEG_SCF_TRCP1_1	510:515	Mutation rewiring degron network	0.25
p.R507H	DO47767	STAD	ICGC	DSGLHS	DEG_SCF_TRCP1_1	510:515	Mutation rewiring degron network	0.25
p.R507H	SIDM00596	Endometrial Carcinoma	GDSC	DSGLHS	DEG_SCF_TRCP1_1	510:515	Mutation rewiring degron network	0.25
p.R507H	HEC-1	endometrium	COSMIC	DSGLHS	DEG_SCF_TRCP1_1	510:515	Mutation rewiring degron network	0.25
p.D510Y	TCGA-NJ-A55A	LUAD	TCGA	DSGLHS	DEG_SCF_TRCP1_1	510:515	Mutation altering degron motif	0.7325
p.D510Y	DO218945	LUAD	ICGC	DSGLHS	DEG_SCF_TRCP1_1	510:515	Mutation altering degron motif	0.7325
p.G438D	TCGA-XK-AAIW	PRAD	TCGA	KRFNLLGIK	DEG_APCC_DBOX_1	442:450	Mutation rewiring degron network	0.2222
p.G438D	DO51407	PRAD	ICGC	KRFNLLGIK	DEG_APCC_DBOX_1	442:450	Mutation rewiring degron network	0.2222
p.Y460C	DO233724	GACA	ICGC	KRFNLLGIK	DEG_APCC_DBOX_1	442:450	Mutation rewiring degron network	0.0556
p.G438V	DO229015	LICA	ICGC	KRFNLLGIK	DEG_APCC_DBOX_1	442:450	Mutation rewiring degron network	0.2222
p.G512R	DO230529	LUSC	ICGC	DSGLHS	DEG_SCF_TRCP1_1	510:515	Mutation altering degron motif	0.7568
p.G512R	DO228529	MALY	ICGC	DSGLHS	DEG_SCF_TRCP1_1	510:515	Mutation altering degron motif	0.7568
p.R451K	DO230999	LUSC	ICGC	KRFNLLGIK	DEG_APCC_DBOX_1	442:450	Mutation rewiring degron network	0.3056
p.R451K	DO224551	LUSC	ICGC	KRFNLLGIK	DEG_APCC_DBOX_1	442:450	Mutation rewiring degron network	0.3056
p.S454N	DO35442	PACA	ICGC	KRFNLLGIK	DEG_APCC_DBOX_1	442:450	Mutation rewiring degron network	0.2222
p.A440T	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	KRFNLLGIK	DEG_APCC_DBOX_1	442:450	Mutation rewiring degron network	0.2778
p.A440T	ACH-000980	Lung Cancer	CCLE	KRFNLLGIK	DEG_APCC_DBOX_1	442:450	Mutation rewiring degron network	0.2778
p.A440T	NCI-H1155	lung	COSMIC	KRFNLLGIK	DEG_APCC_DBOX_1	442:450	Mutation rewiring degron network	0.2778
p.R443M	ACH-001664	Gastric Cancer	CCLE	KRFNLLGIK	DEG_APCC_DBOX_1	442:450	Mutation altering degron motif	0.8632

Kaplan plot for ZNF407 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZNF407

UniProt ID: Q9C0G0

Entrez ID: 55628

Protein name: Zinc finger protein 407

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZNF407 in