DegronMD

Uniprot ID: Q9C0G0

Source protein: Zinc finger protein 407

Source gene: ZNF407

Class: DEG_APCC_DBOX_1

Location: 442:450

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8955

ASA_SCORE: 108.8556

COIL: 0.8008

CONS_SCORE: 0.5532

DSS_SCORE: 0.4528

HELIX: 0.0266

FCONS_SCORE: 0.9168

RIG_SCORE: 0.8016

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q457K	TCGA-A3-A6NL	KIRC	TCGA	KRFNLLGIK	DEG_APCC_DBOX_1	0.1389
p.Q457K	DO50458	KIRC	ICGC	KRFNLLGIK	DEG_APCC_DBOX_1	0.1389
p.G438D	TCGA-XK-AAIW	PRAD	TCGA	KRFNLLGIK	DEG_APCC_DBOX_1	0.2222
p.G438D	DO51407	PRAD	ICGC	KRFNLLGIK	DEG_APCC_DBOX_1	0.2222
p.Y460C	DO233724	GACA	ICGC	KRFNLLGIK	DEG_APCC_DBOX_1	0.0556
p.G438V	DO229015	LICA	ICGC	KRFNLLGIK	DEG_APCC_DBOX_1	0.2222
p.R451K	DO230999	LUSC	ICGC	KRFNLLGIK	DEG_APCC_DBOX_1	0.3056
p.R451K	DO224551	LUSC	ICGC	KRFNLLGIK	DEG_APCC_DBOX_1	0.3056
p.S454N	DO35442	PACA	ICGC	KRFNLLGIK	DEG_APCC_DBOX_1	0.2222
p.A440T	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	KRFNLLGIK	DEG_APCC_DBOX_1	0.2778
p.A440T	ACH-000980	Lung Cancer	CCLE	KRFNLLGIK	DEG_APCC_DBOX_1	0.2778
p.A440T	NCI-H1155	lung	COSMIC	KRFNLLGIK	DEG_APCC_DBOX_1	0.2778
p.R443M	ACH-001664	Gastric Cancer	CCLE	KRFNLLGIK	DEG_APCC_DBOX_1	0.8632

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9C0G0	Zinc finger protein 407	DEG_APCC_DBOX_1	442:450	KRFNLLGIK	APC,CDC20,FZR1	0.8955	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons