DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
DSGLLPT
Uniprot ID:
Q9H3T3
Source protein:
Semaphorin-6B
Source gene:
SEMA6B
Class:
DEG_SCF_TRCP1_1
Location:
703:709
E3 ligase:
BTRC
DEGRON score:
0.9975
ASA_SCORE:
57.9
COIL:
0.9069
CONS_SCORE:
0.448
DSS_SCORE:
0.7414
HELIX:
0.0489
FCONS_SCORE:
1.18
RIG_SCORE:
0.6271
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.R719H
DO232224
PBCA
ICGC
DSGLLPT
DEG_SCF_TRCP1_1
0.0556
Drug responses associated with SEMA6B mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DSGLLPT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9H3T3
Semaphorin-6B
DEG_SCF_TRCP1_1
703:709
DSGLLPT
BTRC
0.9975
More...