DegronMD - Q9H3T3(SEMA6B)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V800G	DO218478	BRCA	ICGC	PLTPHAS	DEG_SCF_FBW7_1	788:794	Mutation rewiring degron network	0.1667
p.L789F	DO50970	LICA	ICGC	PLTPHAS	DEG_SCF_FBW7_1	788:794	Mutation altering degron motif	0.587
p.V801E	DO52679	MALY	ICGC	PLTPHAS	DEG_SCF_FBW7_1	788:794	Mutation rewiring degron network	0.1389
p.G780S	DO222363	MELA	ICGC	PLTPHAS	DEG_SCF_FBW7_1	788:794	Mutation rewiring degron network	0.1111
p.R719H	DO232224	PBCA	ICGC	LLPTPEQT	DEG_SCF_FBW7_1	706:713	Mutation rewiring degron network	0.1667
p.R719H	DO232224	PBCA	ICGC	DSGLLPT	DEG_SCF_TRCP1_1	703:709	Mutation rewiring degron network	0.0556
p.R781L	SIDM00910	Neuroblastoma	GDSC	PLTPHAS	DEG_SCF_FBW7_1	788:794	Mutation rewiring degron network	0.1389
p.A803V	ACH-000973	Bladder Cancer	CCLE	PLTPHAS	DEG_SCF_FBW7_1	788:794	Mutation rewiring degron network	0.0833

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons