DegronMD

Uniprot ID: Q9H3T3

Source protein: Semaphorin-6B

Source gene: SEMA6B

Class: DEG_SCF_FBW7_1

Location: 788:794

E3 ligase: FBXW7

DEGRON score: 0.9673

ASA_SCORE: 74.7857

COIL: 0.9123

CONS_SCORE: 0.3567

DSS_SCORE: 0.7028

HELIX: 0.0163

FCONS_SCORE: 0.9443

RIG_SCORE: 0.6221

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V800G	DO218478	BRCA	ICGC	PLTPHAS	DEG_SCF_FBW7_1	0.1667
p.L789F	DO50970	LICA	ICGC	PLTPHAS	DEG_SCF_FBW7_1	0.587
p.V801E	DO52679	MALY	ICGC	PLTPHAS	DEG_SCF_FBW7_1	0.1389
p.G780S	DO222363	MELA	ICGC	PLTPHAS	DEG_SCF_FBW7_1	0.1111
p.R781L	SIDM00910	Neuroblastoma	GDSC	PLTPHAS	DEG_SCF_FBW7_1	0.1389
p.A803V	ACH-000973	Bladder Cancer	CCLE	PLTPHAS	DEG_SCF_FBW7_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H3T3	Semaphorin-6B	DEG_SCF_FBW7_1	788:794	PLTPHAS	FBXW7	0.9673	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons