DegronMD

Uniprot ID: O43147

Source protein: Small G protein signaling modulator 2

Source gene: SGSM2

Class: DEG_SCF_TRCP1_1

Location: 704:710

E3 ligase: BTRC

DEGRON score: 0.9808

ASA_SCORE: 75.2857

COIL: 0.8556

CONS_SCORE: 0.2981

DSS_SCORE: 0.6229

HELIX: 0.0966

FCONS_SCORE: 1.0421

RIG_SCORE: 0.6127

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P710L	TCGA-FS-A4F0	SKCM	TCGA	DSGLPSS	DEG_SCF_TRCP1_1	0.7582
p.D718A	TCGA-HU-A4H4	STAD	TCGA	DSGLPSS	DEG_SCF_TRCP1_1	0.1111
p.V698M	DO233737	GACA	ICGC	DSGLPSS	DEG_SCF_TRCP1_1	0.1667
p.G718C	DO229018	LICA	ICGC	DSGLPSS	DEG_SCF_TRCP1_1	0.1111
p.D701N	DO45390	LUAD	ICGC	DSGLPSS	DEG_SCF_TRCP1_1	0.25
p.P708R	DO46493	OV	ICGC	DSGLPSS	DEG_SCF_TRCP1_1	0.6401
p.S717P	DO229242	THCA	ICGC	DSGLPSS	DEG_SCF_TRCP1_1	0.1389
p.E712D	SIDM00557	Neuroblastoma	GDSC	DSGLPSS	DEG_SCF_TRCP1_1	0.2778
p.E712D	SIDM00291	Melanoma	GDSC	DSGLPSS	DEG_SCF_TRCP1_1	0.2778
p.E712D	SIDM01413	Oral Cavity Carcinoma	GDSC	DSGLPSS	DEG_SCF_TRCP1_1	0.2778
p.E712D	SIDM01451	Pancreatic Carcinoma	GDSC	DSGLPSS	DEG_SCF_TRCP1_1	0.2778
p.E712D	SIDM01762	Esophageal Squamous Cell Carcinoma	GDSC	DSGLPSS	DEG_SCF_TRCP1_1	0.2778
p.E712D	HMV-II	skin	COSMIC	DSGLPSS	DEG_SCF_TRCP1_1	0.2778
p.E712D	KP-N-RT-BM-1	autonomic_ganglia	COSMIC	DSGLPSS	DEG_SCF_TRCP1_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43147	Small G protein signaling modulator 2	DEG_SCF_TRCP1_1	704:710	DSGLPSS	BTRC	0.9808	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons