DegronMD

Uniprot ID: A1X283

Source protein: SH3 and PX domain-containing protein 2B

Source gene: SH3PXD2B

Class: DEG_SCF_TRCP1_1

Location: 479:485

E3 ligase: BTRC

DEGRON score: 0.9022

ASA_SCORE: 64.6857

COIL: 0.8344

CONS_SCORE: 0.394

DSS_SCORE: 0.5359

HELIX: 0.0939

FCONS_SCORE: 0.9051

RIG_SCORE: 0.6894

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G481V	TCGA-44-8119	LUAD	TCGA	DSGLPWS	DEG_SCF_TRCP1_1	0.7532
p.G481V	DO24399	LUAD	ICGC	DSGLPWS	DEG_SCF_TRCP1_1	0.7532
p.P471S	TCGA-A7-A6VY	BRCA	TCGA	DSGLPWS	DEG_SCF_TRCP1_1	0.1111
p.P471S	DO50021	BRCA	ICGC	DSGLPWS	DEG_SCF_TRCP1_1	0.1111
p.W488C	TCGA-AN-A0XS	BRCA	TCGA	DSGLPWS	DEG_SCF_TRCP1_1	0.25
p.W488C	DO3322	BRCA	ICGC	DSGLPWS	DEG_SCF_TRCP1_1	0.25
p.S480L	TCGA-F5-6814	READ	TCGA	DSGLPWS	DEG_SCF_TRCP1_1	0.7667
p.S480L	DO36556	READ	ICGC	DSGLPWS	DEG_SCF_TRCP1_1	0.7667
p.D487E	TCGA-FI-A2D0	UCEC	TCGA	DSGLPWS	DEG_SCF_TRCP1_1	0.2778
p.D487E	DO43891	UCEC	ICGC	DSGLPWS	DEG_SCF_TRCP1_1	0.2778
p.A473T	DO233146	GACA	ICGC	DSGLPWS	DEG_SCF_TRCP1_1	0.1667
p.H475N	DO228974	LICA	ICGC	DSGLPWS	DEG_SCF_TRCP1_1	0.2222
p.G481R	SIDM00834	Colorectal Carcinoma	GDSC	DSGLPWS	DEG_SCF_TRCP1_1	0.7568
p.S491N	SIDM00224	Mesothelioma	GDSC	DSGLPWS	DEG_SCF_TRCP1_1	0.6111
p.S491N	ACH-000569	Lung Cancer	CCLE	DSGLPWS	DEG_SCF_TRCP1_1	0.6111
p.S491N	IST-MES1	pleura	COSMIC	DSGLPWS	DEG_SCF_TRCP1_1	0.6111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A1X283	SH3 and PX domain-containing protein 2B	DEG_SCF_TRCP1_1	479:485	DSGLPWS	BTRC	0.9022	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons