DegronMD - A1X283(SH3PXD2B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G481V	TCGA-44-8119	LUAD	TCGA	DSGLPWS	DEG_SCF_TRCP1_1	479:485	Mutation altering degron motif	0.7532
p.G481V	DO24399	LUAD	ICGC	DSGLPWS	DEG_SCF_TRCP1_1	479:485	Mutation altering degron motif	0.7532
p.T428K	TCGA-61-2092	OV	TCGA	LAPLPHEVTQLRL	DEG_ODPH_VHL_1	437:449	Mutation rewiring degron network	0.0833
p.T428K	DO32449	OV	ICGC	LAPLPHEVTQLRL	DEG_ODPH_VHL_1	437:449	Mutation rewiring degron network	0.0833
p.P471S	TCGA-A7-A6VY	BRCA	TCGA	DSGLPWS	DEG_SCF_TRCP1_1	479:485	Mutation rewiring degron network	0.1111
p.P471S	DO50021	BRCA	ICGC	DSGLPWS	DEG_SCF_TRCP1_1	479:485	Mutation rewiring degron network	0.1111
p.P441L	TCGA-AA-3715	COAD	TCGA	LAPLPHEVTQLRL	DEG_ODPH_VHL_1	437:449	Mutation altering degron motif	0.6471
p.P441L	DO8018	COAD	ICGC	LAPLPHEVTQLRL	DEG_ODPH_VHL_1	437:449	Mutation altering degron motif	0.6471
p.W488C	TCGA-AN-A0XS	BRCA	TCGA	DSGLPWS	DEG_SCF_TRCP1_1	479:485	Mutation rewiring degron network	0.25
p.W488C	DO3322	BRCA	ICGC	DSGLPWS	DEG_SCF_TRCP1_1	479:485	Mutation rewiring degron network	0.25
p.H442Y	TCGA-AP-A1DK	UCEC	TCGA	LAPLPHEVTQLRL	DEG_ODPH_VHL_1	437:449	Mutation altering degron motif	0.6118
p.H442Y	DO42033	UCEC	ICGC	LAPLPHEVTQLRL	DEG_ODPH_VHL_1	437:449	Mutation altering degron motif	0.6118
p.A454V	TCGA-AX-A06F	UCEC	TCGA	LAPLPHEVTQLRL	DEG_ODPH_VHL_1	437:449	Mutation rewiring degron network	0.1944
p.A454V	DO41752	UCEC	ICGC	LAPLPHEVTQLRL	DEG_ODPH_VHL_1	437:449	Mutation rewiring degron network	0.1944
p.E456D	TCGA-AX-A2HC	UCEC	TCGA	LAPLPHEVTQLRL	DEG_ODPH_VHL_1	437:449	Mutation rewiring degron network	0.1389
p.E456D	DO41572	UCEC	ICGC	LAPLPHEVTQLRL	DEG_ODPH_VHL_1	437:449	Mutation rewiring degron network	0.1389
p.S429G	TCGA-BR-7901	STAD	TCGA	LAPLPHEVTQLRL	DEG_ODPH_VHL_1	437:449	Mutation rewiring degron network	0.1111
p.S429G	DO38463	STAD	ICGC	LAPLPHEVTQLRL	DEG_ODPH_VHL_1	437:449	Mutation rewiring degron network	0.1111
p.P439T	TCGA-CA-6717	COAD	TCGA	LAPLPHEVTQLRL	DEG_ODPH_VHL_1	437:449	Mutation altering degron motif	0.7031
p.P439T	DO8264	COAD	ICGC	LAPLPHEVTQLRL	DEG_ODPH_VHL_1	437:449	Mutation altering degron motif	0.7031
p.E443K	TCGA-DK-A1AD	BLCA	TCGA	LAPLPHEVTQLRL	DEG_ODPH_VHL_1	437:449	Mutation altering degron motif	0.591
p.E443K	DO459	BLCA	ICGC	LAPLPHEVTQLRL	DEG_ODPH_VHL_1	437:449	Mutation altering degron motif	0.591
p.S480L	TCGA-F5-6814	READ	TCGA	DSGLPWS	DEG_SCF_TRCP1_1	479:485	Mutation altering degron motif	0.7667
p.S480L	DO36556	READ	ICGC	DSGLPWS	DEG_SCF_TRCP1_1	479:485	Mutation altering degron motif	0.7667
p.D487E	TCGA-FI-A2D0	UCEC	TCGA	DSGLPWS	DEG_SCF_TRCP1_1	479:485	Mutation rewiring degron network	0.2778
p.D487E	DO43891	UCEC	ICGC	DSGLPWS	DEG_SCF_TRCP1_1	479:485	Mutation rewiring degron network	0.2778
p.G450V	TCGA-HE-7130	KIRP	TCGA	LAPLPHEVTQLRL	DEG_ODPH_VHL_1	437:449	Mutation rewiring degron network	0.3056
p.G450V	DO20776	KIRP	ICGC	LAPLPHEVTQLRL	DEG_ODPH_VHL_1	437:449	Mutation rewiring degron network	0.3056
p.L455M	TCGA-X6-A7WA	SARC	TCGA	LAPLPHEVTQLRL	DEG_ODPH_VHL_1	437:449	Mutation rewiring degron network	0.1667
p.L455M	DO220312	SARC	ICGC	LAPLPHEVTQLRL	DEG_ODPH_VHL_1	437:449	Mutation rewiring degron network	0.1667
p.A473T	DO233146	GACA	ICGC	DSGLPWS	DEG_SCF_TRCP1_1	479:485	Mutation rewiring degron network	0.1667
p.T428M	DO233898	GACA	ICGC	LAPLPHEVTQLRL	DEG_ODPH_VHL_1	437:449	Mutation rewiring degron network	0.0833
p.T459M	DO233908	GACA	ICGC	LAPLPHEVTQLRL	DEG_ODPH_VHL_1	437:449	Mutation rewiring degron network	0.0556
p.T459M	SIDM01051	Ovarian Carcinoma	GDSC	LAPLPHEVTQLRL	DEG_ODPH_VHL_1	437:449	Mutation rewiring degron network	0.0556
p.T459M	ACH-000936	Ovarian Cancer	CCLE	LAPLPHEVTQLRL	DEG_ODPH_VHL_1	437:449	Mutation rewiring degron network	0.0556
p.T459M	EFO-27	ovary	COSMIC	LAPLPHEVTQLRL	DEG_ODPH_VHL_1	437:449	Mutation rewiring degron network	0.0556
p.H475N	DO228974	LICA	ICGC	DSGLPWS	DEG_SCF_TRCP1_1	479:485	Mutation rewiring degron network	0.2222
p.R448W	DO220896	MELA	ICGC	LAPLPHEVTQLRL	DEG_ODPH_VHL_1	437:449	Mutation altering degron motif	0.7523
p.G481R	SIDM00834	Colorectal Carcinoma	GDSC	DSGLPWS	DEG_SCF_TRCP1_1	479:485	Mutation altering degron motif	0.7568
p.M428V	SIDM00237	Non-Small Cell Lung Carcinoma	GDSC	LAPLPHEVTQLRL	DEG_ODPH_VHL_1	437:449	Mutation rewiring degron network	0.0833
p.M428V	ACH-000030	Lung Cancer	CCLE	LAPLPHEVTQLRL	DEG_ODPH_VHL_1	437:449	Mutation rewiring degron network	0.0833
p.M428V	ACH-000779	Lung Cancer	CCLE	LAPLPHEVTQLRL	DEG_ODPH_VHL_1	437:449	Mutation rewiring degron network	0.0833
p.S491N	SIDM00224	Mesothelioma	GDSC	DSGLPWS	DEG_SCF_TRCP1_1	479:485	Mutation blocking phosphorylation signal	0.6111
p.S491N	ACH-000569	Lung Cancer	CCLE	DSGLPWS	DEG_SCF_TRCP1_1	479:485	Mutation blocking phosphorylation signal	0.6111
p.S491N	IST-MES1	pleura	COSMIC	DSGLPWS	DEG_SCF_TRCP1_1	479:485	Mutation blocking phosphorylation signal	0.6111

Kaplan plot for SH3PXD2B in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SH3PXD2B

UniProt ID: A1X283

Entrez ID: 285590

Protein name: SH3 and PX domain-containing protein 2B (Adapter protein HOFI) (Factor for adipocyte differentiation 49) (Tyrosine kinase substrate with four SH3 domains)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SH3PXD2B in