DegronMD

Uniprot ID: A1X283

Source protein: SH3 and PX domain-containing protein 2B

Source gene: SH3PXD2B

Class: DEG_ODPH_VHL_1

Location: 437:449

E3 ligase: VHL

DEGRON score: 0.9482

ASA_SCORE: 87.7846

COIL: 0.7464

CONS_SCORE: 0.4565

DSS_SCORE: 0.4919

HELIX: 0.1377

FCONS_SCORE: 1.0221

RIG_SCORE: 0.7653

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T428K	TCGA-61-2092	OV	TCGA	LAPLPHEVTQLRL	DEG_ODPH_VHL_1	0.0833
p.T428K	DO32449	OV	ICGC	LAPLPHEVTQLRL	DEG_ODPH_VHL_1	0.0833
p.P441L	TCGA-AA-3715	COAD	TCGA	LAPLPHEVTQLRL	DEG_ODPH_VHL_1	0.6471
p.P441L	DO8018	COAD	ICGC	LAPLPHEVTQLRL	DEG_ODPH_VHL_1	0.6471
p.H442Y	TCGA-AP-A1DK	UCEC	TCGA	LAPLPHEVTQLRL	DEG_ODPH_VHL_1	0.6118
p.H442Y	DO42033	UCEC	ICGC	LAPLPHEVTQLRL	DEG_ODPH_VHL_1	0.6118
p.A454V	TCGA-AX-A06F	UCEC	TCGA	LAPLPHEVTQLRL	DEG_ODPH_VHL_1	0.1944
p.A454V	DO41752	UCEC	ICGC	LAPLPHEVTQLRL	DEG_ODPH_VHL_1	0.1944
p.E456D	TCGA-AX-A2HC	UCEC	TCGA	LAPLPHEVTQLRL	DEG_ODPH_VHL_1	0.1389
p.E456D	DO41572	UCEC	ICGC	LAPLPHEVTQLRL	DEG_ODPH_VHL_1	0.1389
p.S429G	TCGA-BR-7901	STAD	TCGA	LAPLPHEVTQLRL	DEG_ODPH_VHL_1	0.1111
p.S429G	DO38463	STAD	ICGC	LAPLPHEVTQLRL	DEG_ODPH_VHL_1	0.1111
p.P439T	TCGA-CA-6717	COAD	TCGA	LAPLPHEVTQLRL	DEG_ODPH_VHL_1	0.7031
p.P439T	DO8264	COAD	ICGC	LAPLPHEVTQLRL	DEG_ODPH_VHL_1	0.7031
p.E443K	TCGA-DK-A1AD	BLCA	TCGA	LAPLPHEVTQLRL	DEG_ODPH_VHL_1	0.591
p.E443K	DO459	BLCA	ICGC	LAPLPHEVTQLRL	DEG_ODPH_VHL_1	0.591
p.G450V	TCGA-HE-7130	KIRP	TCGA	LAPLPHEVTQLRL	DEG_ODPH_VHL_1	0.3056
p.G450V	DO20776	KIRP	ICGC	LAPLPHEVTQLRL	DEG_ODPH_VHL_1	0.3056
p.L455M	TCGA-X6-A7WA	SARC	TCGA	LAPLPHEVTQLRL	DEG_ODPH_VHL_1	0.1667
p.L455M	DO220312	SARC	ICGC	LAPLPHEVTQLRL	DEG_ODPH_VHL_1	0.1667
p.T428M	DO233898	GACA	ICGC	LAPLPHEVTQLRL	DEG_ODPH_VHL_1	0.0833
p.T459M	DO233908	GACA	ICGC	LAPLPHEVTQLRL	DEG_ODPH_VHL_1	0.0556
p.T459M	SIDM01051	Ovarian Carcinoma	GDSC	LAPLPHEVTQLRL	DEG_ODPH_VHL_1	0.0556
p.T459M	ACH-000936	Ovarian Cancer	CCLE	LAPLPHEVTQLRL	DEG_ODPH_VHL_1	0.0556
p.T459M	EFO-27	ovary	COSMIC	LAPLPHEVTQLRL	DEG_ODPH_VHL_1	0.0556
p.R448W	DO220896	MELA	ICGC	LAPLPHEVTQLRL	DEG_ODPH_VHL_1	0.7523
p.M428V	SIDM00237	Non-Small Cell Lung Carcinoma	GDSC	LAPLPHEVTQLRL	DEG_ODPH_VHL_1	0.0833
p.M428V	ACH-000030	Lung Cancer	CCLE	LAPLPHEVTQLRL	DEG_ODPH_VHL_1	0.0833
p.M428V	ACH-000779	Lung Cancer	CCLE	LAPLPHEVTQLRL	DEG_ODPH_VHL_1	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LAPLPHEVTQLRL

Degron related mutations and impact score

Drug responses associated with SH3PXD2B mutations

All proteins holding degron of LAPLPHEVTQLRL

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A1X283	SH3 and PX domain-containing protein 2B	DEG_ODPH_VHL_1	437:449	LAPLPHEVTQLRL	VHL	0.9482	More...