DegronMD

Uniprot ID: O75478

Source protein: Transcriptional adapter 2-alpha

Source gene: TADA2A

Class: DEG_SCF_TRCP1_1

Location: 344:350

E3 ligase: BTRC

DEGRON score: 0.983

ASA_SCORE: 53.6571

COIL: 0.7771

CONS_SCORE: 0.5448

DSS_SCORE: 0.5163

HELIX: 0.1116

FCONS_SCORE: 1.095

RIG_SCORE: 0.6509

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R360Q	TCGA-32-2494	GBM	TCGA	DSGLSPS	DEG_SCF_TRCP1_1	0.0556
p.R360Q	TCGA-A5-A0G1	UCEC	TCGA	DSGLSPS	DEG_SCF_TRCP1_1	0.0556
p.R360Q	DO11998	GBM	ICGC	DSGLSPS	DEG_SCF_TRCP1_1	0.0556
p.R360Q	DO42472	UCEC	ICGC	DSGLSPS	DEG_SCF_TRCP1_1	0.0556
p.R359K	TCGA-B5-A11R	UCEC	TCGA	DSGLSPS	DEG_SCF_TRCP1_1	0.0833
p.R359K	DO43787	UCEC	ICGC	DSGLSPS	DEG_SCF_TRCP1_1	0.0833
p.R338C	TCGA-EE-A2GJ	SKCM	TCGA	DSGLSPS	DEG_SCF_TRCP1_1	0.1667
p.R338C	DO37746	SKCM	ICGC	DSGLSPS	DEG_SCF_TRCP1_1	0.1667
p.G358D	TCGA-XF-AAMX	BLCA	TCGA	DSGLSPS	DEG_SCF_TRCP1_1	0.1111
p.G358D	DO51939	BLCA	ICGC	DSGLSPS	DEG_SCF_TRCP1_1	0.1111
p.W336L	DO1094	BRCA	ICGC	DSGLSPS	DEG_SCF_TRCP1_1	0.1111
p.S355L	DO233764	GACA	ICGC	DSGLSPS	DEG_SCF_TRCP1_1	0.1944
p.P349S	DO229465	SKCA	ICGC	DSGLSPS	DEG_SCF_TRCP1_1	0.5641
p.I351M	SIDM00068	Colorectal Carcinoma	GDSC	DSGLSPS	DEG_SCF_TRCP1_1	0.3056
p.I351M	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	DSGLSPS	DEG_SCF_TRCP1_1	0.3056
p.I351M	SIDM01173	Rhabdomyosarcoma	GDSC	DSGLSPS	DEG_SCF_TRCP1_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75478	Transcriptional adapter 2-alpha	DEG_SCF_TRCP1_1	344:350	DSGLSPS	BTRC	0.983	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons