DegronMD

Uniprot ID: Q9UJX6

Source protein: Anaphase-promoting complex subunit 2

Source gene: ANAPC2

Class: DEG_SCF_TRCP1_1

Location: 737:742

E3 ligase: BTRC

DEGRON score: 0.6914

ASA_SCORE: 80.25

COIL: 0.666

CONS_SCORE: 0.2769

DSS_SCORE: 0.6905

HELIX: 0.322

FCONS_SCORE: 1.0589

RIG_SCORE: 0.6477

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E735D	TCGA-A3-A6NL	KIRC	TCGA	DSGMAS	DEG_SCF_TRCP1_1	0.2778
p.E735D	DO50458	KIRC	ICGC	DSGMAS	DEG_SCF_TRCP1_1	0.2778
p.Q743H	TCGA-BR-7707	STAD	TCGA	DSGMAS	DEG_SCF_TRCP1_1	0.3056
p.Q743H	DO232861	NACA	ICGC	DSGMAS	DEG_SCF_TRCP1_1	0.3056
p.Q743H	DO38487	STAD	ICGC	DSGMAS	DEG_SCF_TRCP1_1	0.3056
p.S738C	TCGA-DK-AA6L	BLCA	TCGA	DSGMAS	DEG_SCF_TRCP1_1	0.7541
p.S738C	DO219002	BLCA	ICGC	DSGMAS	DEG_SCF_TRCP1_1	0.7541
p.D731N	DO228331	BRCA	ICGC	DSGMAS	DEG_SCF_TRCP1_1	0.1667
p.S742C	DO232861	NACA	ICGC	DSGMAS	DEG_SCF_TRCP1_1	0.7541
p.E750D	SIDM01147	Gastric Carcinoma	GDSC	DSGMAS	DEG_SCF_TRCP1_1	0.1111
p.E750D	ACH-000427	Gastric Cancer	CCLE	DSGMAS	DEG_SCF_TRCP1_1	0.1111
p.E750D	NCI-N87	stomach	COSMIC	DSGMAS	DEG_SCF_TRCP1_1	0.1111
p.D734N	SIDM00256	Neuroblastoma	GDSC	DSGMAS	DEG_SCF_TRCP1_1	0.25
p.D734N	ACH-002281	Neuroblastoma	CCLE	DSGMAS	DEG_SCF_TRCP1_1	0.25
p.D734N	NB14	autonomic_ganglia	COSMIC	DSGMAS	DEG_SCF_TRCP1_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UJX6	Anaphase-promoting complex subunit 2	DEG_SCF_TRCP1_1	737:742	DSGMAS	BTRC	0.6914	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons