DegronMD - Q9UJX6(ANAPC2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P477S	TCGA-2G-AALP	TGCT	TCGA	EPEDWVPDP	DEG_COP1_1	476:484	Mutation altering degron motif	0.5641
p.E735D	TCGA-A3-A6NL	KIRC	TCGA	DSGMAS	DEG_SCF_TRCP1_1	737:742	Mutation rewiring degron network	0.2778
p.E735D	DO50458	KIRC	ICGC	DSGMAS	DEG_SCF_TRCP1_1	737:742	Mutation rewiring degron network	0.2778
p.P482L	TCGA-AY-6197	COAD	TCGA	EPEDWVPDP	DEG_COP1_1	476:484	Mutation altering degron motif	0.7582
p.P482L	DO9956	COAD	ICGC	EPEDWVPDP	DEG_COP1_1	476:484	Mutation altering degron motif	0.7582
p.Q743H	TCGA-BR-7707	STAD	TCGA	DSGMAS	DEG_SCF_TRCP1_1	737:742	Mutation rewiring degron network	0.3056
p.Q743H	DO232861	NACA	ICGC	DSGMAS	DEG_SCF_TRCP1_1	737:742	Mutation rewiring degron network	0.3056
p.Q743H	DO38487	STAD	ICGC	DSGMAS	DEG_SCF_TRCP1_1	737:742	Mutation rewiring degron network	0.3056
p.S738C	TCGA-DK-AA6L	BLCA	TCGA	DSGMAS	DEG_SCF_TRCP1_1	737:742	Mutation altering degron motif	0.7541
p.S738C	DO219002	BLCA	ICGC	DSGMAS	DEG_SCF_TRCP1_1	737:742	Mutation altering degron motif	0.7541
p.P482Q	TCGA-FS-A1ZC	SKCM	TCGA	EPEDWVPDP	DEG_COP1_1	476:484	Mutation altering degron motif	0.7035
p.P482Q	DO37487	SKCM	ICGC	EPEDWVPDP	DEG_COP1_1	476:484	Mutation altering degron motif	0.7035
p.D469N	TCGA-K4-A3WU	BLCA	TCGA	EPEDWVPDP	DEG_COP1_1	476:484	Mutation rewiring degron network	0.1389
p.D469N	DO451	BLCA	ICGC	EPEDWVPDP	DEG_COP1_1	476:484	Mutation rewiring degron network	0.1389
p.A487V	TCGA-WE-A8K1	SKCM	TCGA	EPEDWVPDP	DEG_COP1_1	476:484	Mutation rewiring degron network	0.25
p.A487V	DO51280	SKCM	ICGC	EPEDWVPDP	DEG_COP1_1	476:484	Mutation rewiring degron network	0.25
p.D731N	DO228331	BRCA	ICGC	DSGMAS	DEG_SCF_TRCP1_1	737:742	Mutation rewiring degron network	0.1667
p.S742C	DO232861	NACA	ICGC	DSGMAS	DEG_SCF_TRCP1_1	737:742	Mutation altering degron motif	0.7541
p.D473N	SIDM00319	Melanoma	GDSC	EPEDWVPDP	DEG_COP1_1	476:484	Mutation rewiring degron network	0.25
p.D473N	ACH-001704	Skin Cancer	CCLE	EPEDWVPDP	DEG_COP1_1	476:484	Mutation rewiring degron network	0.25
p.D473N	VMRC-MELG	skin	COSMIC	EPEDWVPDP	DEG_COP1_1	476:484	Mutation rewiring degron network	0.25
p.Q468K	SIDM00728	Non-Small Cell Lung Carcinoma	GDSC	EPEDWVPDP	DEG_COP1_1	476:484	Mutation rewiring degron network	0.1111
p.Q468K	ACH-000718	Lung Cancer	CCLE	EPEDWVPDP	DEG_COP1_1	476:484	Mutation rewiring degron network	0.1111
p.Q468K	NCI-H2291	lung	COSMIC	EPEDWVPDP	DEG_COP1_1	476:484	Mutation rewiring degron network	0.1111
p.D483N	SIDM00892	Breast Carcinoma	GDSC	EPEDWVPDP	DEG_COP1_1	476:484	Mutation altering degron motif	0.6932
p.D483N	ACH-000818	Breast Cancer	CCLE	EPEDWVPDP	DEG_COP1_1	476:484	Mutation altering degron motif	0.6932
p.D483N	BT-483	breast	COSMIC	EPEDWVPDP	DEG_COP1_1	476:484	Mutation altering degron motif	0.6932
p.E750D	SIDM01147	Gastric Carcinoma	GDSC	DSGMAS	DEG_SCF_TRCP1_1	737:742	Mutation rewiring degron network	0.1111
p.E750D	ACH-000427	Gastric Cancer	CCLE	DSGMAS	DEG_SCF_TRCP1_1	737:742	Mutation rewiring degron network	0.1111
p.E750D	NCI-N87	stomach	COSMIC	DSGMAS	DEG_SCF_TRCP1_1	737:742	Mutation rewiring degron network	0.1111
p.D479Y	SIDM00877	Breast Carcinoma	GDSC	EPEDWVPDP	DEG_COP1_1	476:484	Mutation altering degron motif	0.6214
p.D479Y	ACH-000196	Breast Cancer	CCLE	EPEDWVPDP	DEG_COP1_1	476:484	Mutation altering degron motif	0.6214
p.D734N	SIDM00256	Neuroblastoma	GDSC	DSGMAS	DEG_SCF_TRCP1_1	737:742	Mutation rewiring degron network	0.25
p.D734N	ACH-002281	Neuroblastoma	CCLE	DSGMAS	DEG_SCF_TRCP1_1	737:742	Mutation rewiring degron network	0.25
p.D734N	NB14	autonomic ganglia	COSMIC	DSGMAS	DEG_SCF_TRCP1_1	737:742	Mutation rewiring degron network	0.25
p.E471D	SIDM01609	Endometrial Carcinoma	GDSC	EPEDWVPDP	DEG_COP1_1	476:484	Mutation rewiring degron network	0.1944
p.E471D	ACH-000972	Endometrial/Uterine Cancer	CCLE	EPEDWVPDP	DEG_COP1_1	476:484	Mutation rewiring degron network	0.1944
p.D473Y	SIDM01394	Kidney Carcinoma	GDSC	EPEDWVPDP	DEG_COP1_1	476:484	Mutation rewiring degron network	0.25
p.D473Y	ACH-000907	Kidney Cancer	CCLE	EPEDWVPDP	DEG_COP1_1	476:484	Mutation rewiring degron network	0.25

Kaplan plot for ANAPC2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ANAPC2

UniProt ID: Q9UJX6

Entrez ID: 29882

Protein name: Anaphase-promoting complex subunit 2 (APC2) (Cyclosome subunit 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ANAPC2 in