DegronMD

Uniprot ID: Q9UJX6

Source protein: Anaphase-promoting complex subunit 2

Source gene: ANAPC2

Class: DEG_COP1_1

Location: 476:484

E3 ligase: COP1

DEGRON score: 0.9974

ASA_SCORE: 64.3222

COIL: 0.7288

CONS_SCORE: 0.4637

DSS_SCORE: 0.8141

HELIX: 0.2238

FCONS_SCORE: 1.537

RIG_SCORE: 0.66

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P482L	TCGA-AY-6197	COAD	TCGA	EPEDWVPDP	DEG_COP1_1	0.7582
p.P482L	DO9956	COAD	ICGC	EPEDWVPDP	DEG_COP1_1	0.7582
p.P482Q	TCGA-FS-A1ZC	SKCM	TCGA	EPEDWVPDP	DEG_COP1_1	0.7035
p.P482Q	DO37487	SKCM	ICGC	EPEDWVPDP	DEG_COP1_1	0.7035
p.D483N	SIDM00892	Breast Carcinoma	GDSC	EPEDWVPDP	DEG_COP1_1	0.6932
p.D483N	ACH-000818	Breast Cancer	CCLE	EPEDWVPDP	DEG_COP1_1	0.6932
p.D483N	BT-483	breast	COSMIC	EPEDWVPDP	DEG_COP1_1	0.6932
p.D479Y	SIDM00877	Breast Carcinoma	GDSC	EPEDWVPDP	DEG_COP1_1	0.6214
p.D479Y	ACH-000196	Breast Cancer	CCLE	EPEDWVPDP	DEG_COP1_1	0.6214
p.P477S	TCGA-2G-AALP	TGCT	TCGA	EPEDWVPDP	DEG_COP1_1	0.5641
p.A487V	TCGA-WE-A8K1	SKCM	TCGA	EPEDWVPDP	DEG_COP1_1	0.25
p.A487V	DO51280	SKCM	ICGC	EPEDWVPDP	DEG_COP1_1	0.25
p.D473N	SIDM00319	Melanoma	GDSC	EPEDWVPDP	DEG_COP1_1	0.25
p.D473N	ACH-001704	Skin Cancer	CCLE	EPEDWVPDP	DEG_COP1_1	0.25
p.D473N	VMRC-MELG	skin	COSMIC	EPEDWVPDP	DEG_COP1_1	0.25
p.D473Y	SIDM01394	Kidney Carcinoma	GDSC	EPEDWVPDP	DEG_COP1_1	0.25
p.D473Y	ACH-000907	Kidney Cancer	CCLE	EPEDWVPDP	DEG_COP1_1	0.25
p.E471D	SIDM01609	Endometrial Carcinoma	GDSC	EPEDWVPDP	DEG_COP1_1	0.1944
p.E471D	ACH-000972	Endometrial/Uterine Cancer	CCLE	EPEDWVPDP	DEG_COP1_1	0.1944
p.D469N	TCGA-K4-A3WU	BLCA	TCGA	EPEDWVPDP	DEG_COP1_1	0.1389
p.D469N	DO451	BLCA	ICGC	EPEDWVPDP	DEG_COP1_1	0.1389
p.Q468K	SIDM00728	Non-Small Cell Lung Carcinoma	GDSC	EPEDWVPDP	DEG_COP1_1	0.1111
p.Q468K	ACH-000718	Lung Cancer	CCLE	EPEDWVPDP	DEG_COP1_1	0.1111
p.Q468K	NCI-H2291	lung	COSMIC	EPEDWVPDP	DEG_COP1_1	0.1111

Showing 1 to 24 of 24 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UJX6	Anaphase-promoting complex subunit 2	DEG_COP1_1	476:484	EPEDWVPDP	COP1	0.9974	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons