DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
EPEDWVPDP
Uniprot ID:
Q9UJX6
Source protein:
Anaphase-promoting complex subunit 2
Source gene:
ANAPC2
Class:
DEG_COP1_1
Location:
476:484
E3 ligase:
COP1
DEGRON score:
0.9974
ASA_SCORE:
64.3222
COIL:
0.7288
CONS_SCORE:
0.4637
DSS_SCORE:
0.8141
HELIX:
0.2238
FCONS_SCORE:
1.537
RIG_SCORE:
0.66
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P477S
TCGA-2G-AALP
TGCT
TCGA
EPEDWVPDP
DEG_COP1_1
0.5641
p.P482L
TCGA-AY-6197
COAD
TCGA
EPEDWVPDP
DEG_COP1_1
0.7582
p.P482L
DO9956
COAD
ICGC
EPEDWVPDP
DEG_COP1_1
0.7582
p.P482Q
TCGA-FS-A1ZC
SKCM
TCGA
EPEDWVPDP
DEG_COP1_1
0.7035
p.P482Q
DO37487
SKCM
ICGC
EPEDWVPDP
DEG_COP1_1
0.7035
p.D469N
TCGA-K4-A3WU
BLCA
TCGA
EPEDWVPDP
DEG_COP1_1
0.1389
p.D469N
DO451
BLCA
ICGC
EPEDWVPDP
DEG_COP1_1
0.1389
p.A487V
TCGA-WE-A8K1
SKCM
TCGA
EPEDWVPDP
DEG_COP1_1
0.25
p.A487V
DO51280
SKCM
ICGC
EPEDWVPDP
DEG_COP1_1
0.25
p.D473N
SIDM00319
Melanoma
GDSC
EPEDWVPDP
DEG_COP1_1
0.25
p.D473N
ACH-001704
Skin Cancer
CCLE
EPEDWVPDP
DEG_COP1_1
0.25
p.D473N
VMRC-MELG
skin
COSMIC
EPEDWVPDP
DEG_COP1_1
0.25
p.Q468K
SIDM00728
Non-Small Cell Lung Carcinoma
GDSC
EPEDWVPDP
DEG_COP1_1
0.1111
p.Q468K
ACH-000718
Lung Cancer
CCLE
EPEDWVPDP
DEG_COP1_1
0.1111
p.Q468K
NCI-H2291
lung
COSMIC
EPEDWVPDP
DEG_COP1_1
0.1111
p.D483N
SIDM00892
Breast Carcinoma
GDSC
EPEDWVPDP
DEG_COP1_1
0.6932
p.D483N
ACH-000818
Breast Cancer
CCLE
EPEDWVPDP
DEG_COP1_1
0.6932
p.D483N
BT-483
breast
COSMIC
EPEDWVPDP
DEG_COP1_1
0.6932
p.D479Y
SIDM00877
Breast Carcinoma
GDSC
EPEDWVPDP
DEG_COP1_1
0.6214
p.D479Y
ACH-000196
Breast Cancer
CCLE
EPEDWVPDP
DEG_COP1_1
0.6214
p.E471D
SIDM01609
Endometrial Carcinoma
GDSC
EPEDWVPDP
DEG_COP1_1
0.1944
p.E471D
ACH-000972
Endometrial/Uterine Cancer
CCLE
EPEDWVPDP
DEG_COP1_1
0.1944
p.D473Y
SIDM01394
Kidney Carcinoma
GDSC
EPEDWVPDP
DEG_COP1_1
0.25
p.D473Y
ACH-000907
Kidney Cancer
CCLE
EPEDWVPDP
DEG_COP1_1
0.25
Drug responses associated with ANAPC2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of EPEDWVPDP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9UJX6
Anaphase-promoting complex subunit 2
DEG_COP1_1
476:484
EPEDWVPDP
COP1
0.9974
More...