DegronMD

Uniprot ID: Q712K3

Source protein: Ubiquitin-conjugating enzyme E2 R2

Source gene: UBE2R2

Class: DEG_SCF_TRCP1_1

Location: 232:238

E3 ligase: BTRC

DEGRON score: 0.8091

ASA_SCORE: 113.0143

COIL: 0.9744

CONS_SCORE: 0.3728

DSS_SCORE: 0.9885

HELIX: 0.0197

FCONS_SCORE: 0.9409

RIG_SCORE: 0.6084

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E236G	TCGA-AP-A1DK	UCEC	TCGA	DSGNEES	DEG_SCF_TRCP1_1	0.6087
p.E236G	DO42033	UCEC	ICGC	DSGNEES	DEG_SCF_TRCP1_1	0.6087
p.E237D	TCGA-AX-A2IN	UCEC	TCGA	DSGNEES	DEG_SCF_TRCP1_1	0.5647
p.E237D	DO42328	UCEC	ICGC	DSGNEES	DEG_SCF_TRCP1_1	0.5647
p.S238L	TCGA-QS-A5YQ	UCEC	TCGA	DSGNEES	DEG_SCF_TRCP1_1	0.8778
p.S238L	DO49073	UCEC	ICGC	DSGNEES	DEG_SCF_TRCP1_1	0.8778
p.A225S	DO229045	LICA	ICGC	DSGNEES	DEG_SCF_TRCP1_1	0.1389
p.S238T	SIDM00867	Glioblastoma	GDSC	DSGNEES	DEG_SCF_TRCP1_1	0.7116
p.S238T	ACH-000863	Brain Cancer	CCLE	DSGNEES	DEG_SCF_TRCP1_1	0.7116
p.S238T	DBTRG-05MG	central_nervous_system	COSMIC	DSGNEES	DEG_SCF_TRCP1_1	0.7116

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q712K3	Ubiquitin-conjugating enzyme E2 R2	DEG_SCF_TRCP1_1	232:238	DSGNEES	BTRC	0.8091	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons