DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
DSGNKT
Uniprot ID:
Q8NDH2
Source protein:
Leucine-rich repeat transmembrane protein CCDC168
Source gene:
CCDC168
Class:
DEG_SCF_TRCP1_1
Location:
5565:5570
E3 ligase:
BTRC
DEGRON score:
0.5082
ASA_SCORE:
89.2167
COIL:
0.8773
CONS_SCORE:
0
DSS_SCORE:
0.582
HELIX:
0.0313
FCONS_SCORE:
0
RIG_SCORE:
0.6499
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with CCDC168 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DSGNKT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8NDH2
Leucine-rich repeat transmembrane protein CCDC168
DEG_SCF_TRCP1_1
5565:5570
DSGNKT
BTRC
0.5082
More...