DegronMD

Uniprot ID: O75400

Source protein: Pre-mRNA-processing factor 40 homolog A

Source gene: PRPF40A

Class: DEG_SCF_TRCP1_1

Location: 926:932

E3 ligase: BTRC

DEGRON score: 0.9784

ASA_SCORE: 88.3857

COIL: 0.8911

CONS_SCORE: 0.2763

DSS_SCORE: 0.659

HELIX: 0.0756

FCONS_SCORE: 1.0334

RIG_SCORE: 0.5664

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R918H	TCGA-AP-A1DK	UCEC	TCGA	DSGNWDT	DEG_SCF_TRCP1_1	0.1111
p.R918H	DO42033	UCEC	ICGC	DSGNWDT	DEG_SCF_TRCP1_1	0.1111
p.L922V	DO225233	BRCA	ICGC	DSGNWDT	DEG_SCF_TRCP1_1	0.3333
p.R918C	DO233737	GACA	ICGC	DSGNWDT	DEG_SCF_TRCP1_1	0.1111
p.R919G	DO45155	LIRI	ICGC	DSGNWDT	DEG_SCF_TRCP1_1	0.1389
p.D929Y	ACH-001303	Neuroblastoma	CCLE	DSGNWDT	DEG_SCF_TRCP1_1	0.7325

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75400	Pre-mRNA-processing factor 40 homolog A	DEG_SCF_TRCP1_1	926:932	DSGNWDT	BTRC	0.9784	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons