DegronMD - O75400(PRPF40A)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R918H	TCGA-AP-A1DK	UCEC	TCGA	DSGNWDT	DEG_SCF_TRCP1_1	926:932	Mutation rewiring degron network	0.1111
p.R918H	DO42033	UCEC	ICGC	DSGNWDT	DEG_SCF_TRCP1_1	926:932	Mutation rewiring degron network	0.1111
p.T318A	TCGA-D1-A16X	UCEC	TCGA	SGTVPVVPEP	DEG_COP1_1	307:316	Mutation rewiring degron network	0.2778
p.T318A	DO41799	UCEC	ICGC	SGTVPVVPEP	DEG_COP1_1	307:316	Mutation rewiring degron network	0.2778
p.T318A	SIDM01525	Acute Myeloid Leukemia	GDSC	SGTVPVVPEP	DEG_COP1_1	307:316	Mutation rewiring degron network	0.2778
p.T318A	ACH-000557	Leukemia	CCLE	SGTVPVVPEP	DEG_COP1_1	307:316	Mutation rewiring degron network	0.2778
p.L922V	DO225233	BRCA	ICGC	DSGNWDT	DEG_SCF_TRCP1_1	926:932	Mutation substituting flanking lysine	0.3333
p.R918C	DO233737	GACA	ICGC	DSGNWDT	DEG_SCF_TRCP1_1	926:932	Mutation rewiring degron network	0.1111
p.R919G	DO45155	LIRI	ICGC	DSGNWDT	DEG_SCF_TRCP1_1	926:932	Mutation rewiring degron network	0.1389
p.A320T	SIDM00541	Colorectal Carcinoma	GDSC	SGTVPVVPEP	DEG_COP1_1	307:316	Mutation rewiring degron network	0.2222
p.A320T	ACH-000926	Colon/Colorectal Cancer	CCLE	SGTVPVVPEP	DEG_COP1_1	307:316	Mutation rewiring degron network	0.2222
p.A320T	HT55	large intestine	COSMIC	SGTVPVVPEP	DEG_COP1_1	307:316	Mutation rewiring degron network	0.2222
p.Q324H	SIDM00946	T-Lymphoblastic Leukemia	GDSC	SGTVPVVPEP	DEG_COP1_1	307:316	Mutation rewiring degron network	0.1111
p.Q324H	ACH-000981	Leukemia	CCLE	SGTVPVVPEP	DEG_COP1_1	307:316	Mutation rewiring degron network	0.1111
p.Q324H	DND-41	haematopoietic and lymphoid tissue	COSMIC	SGTVPVVPEP	DEG_COP1_1	307:316	Mutation rewiring degron network	0.1111
p.D929Y	ACH-001303	Neuroblastoma	CCLE	DSGNWDT	DEG_SCF_TRCP1_1	926:932	Mutation altering degron motif	0.7325
p.T309S	ACH-001430	Bone Cancer	CCLE	SGTVPVVPEP	DEG_COP1_1	307:316	Mutation altering degron motif	0.6005

Kaplan plot for PRPF40A in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PRPF40A

UniProt ID: O75400

Entrez ID: 55660

Protein name: Pre-mRNA-processing factor 40 homolog A (Fas ligand-associated factor 1) (Formin-binding protein 11) (Formin-binding protein 3) (Huntingtin yeast partner A) (Huntingtin-interacting protein 10) (HIP-10) (Huntingtin-interacting protein A) (Renal carcinoma antigen NY-REN-6)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PRPF40A in