DegronMD

Uniprot ID: O75400

Source protein: Pre-mRNA-processing factor 40 homolog A

Source gene: PRPF40A

Class: DEG_COP1_1

Location: 307:316

E3 ligase: COP1

DEGRON score: 0.994

ASA_SCORE: 85.72

COIL: 0.9472

CONS_SCORE: 0.118

DSS_SCORE: 0.415

HELIX: 0.0167

FCONS_SCORE: 0.7687

RIG_SCORE: 0.7123

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T318A	TCGA-D1-A16X	UCEC	TCGA	SGTVPVVPEP	DEG_COP1_1	0.2778
p.T318A	DO41799	UCEC	ICGC	SGTVPVVPEP	DEG_COP1_1	0.2778
p.T318A	SIDM01525	Acute Myeloid Leukemia	GDSC	SGTVPVVPEP	DEG_COP1_1	0.2778
p.T318A	ACH-000557	Leukemia	CCLE	SGTVPVVPEP	DEG_COP1_1	0.2778
p.A320T	SIDM00541	Colorectal Carcinoma	GDSC	SGTVPVVPEP	DEG_COP1_1	0.2222
p.A320T	ACH-000926	Colon/Colorectal Cancer	CCLE	SGTVPVVPEP	DEG_COP1_1	0.2222
p.A320T	HT55	large_intestine	COSMIC	SGTVPVVPEP	DEG_COP1_1	0.2222
p.Q324H	SIDM00946	T-Lymphoblastic Leukemia	GDSC	SGTVPVVPEP	DEG_COP1_1	0.1111
p.Q324H	ACH-000981	Leukemia	CCLE	SGTVPVVPEP	DEG_COP1_1	0.1111
p.Q324H	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	SGTVPVVPEP	DEG_COP1_1	0.1111
p.T309S	ACH-001430	Bone Cancer	CCLE	SGTVPVVPEP	DEG_COP1_1	0.6005

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75400	Pre-mRNA-processing factor 40 homolog A	DEG_COP1_1	307:316	SGTVPVVPEP	COP1	0.994	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons