DegronMD

Uniprot ID: Q8N9B5

Source protein: Junction-mediating and -regulatory protein

Source gene: JMY

Class: DEG_SCF_TRCP1_1

Location: 831:836

E3 ligase: BTRC

DEGRON score: 0.7808

ASA_SCORE: 90.4333

COIL: 0.9498

CONS_SCORE: 0.3502

DSS_SCORE: 0.8186

HELIX: 0.0305

FCONS_SCORE: 0.7805

RIG_SCORE: 0.5487

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R843I	TCGA-44-2656	LUAD	TCGA	DSGPET	DEG_SCF_TRCP1_1	0.1389
p.R843I	DO26052	LUAD	ICGC	DSGPET	DEG_SCF_TRCP1_1	0.1389
p.P823L	TCGA-A4-8630	KIRP	TCGA	DSGPET	DEG_SCF_TRCP1_1	0.1111
p.P823L	DO44489	KIRP	ICGC	DSGPET	DEG_SCF_TRCP1_1	0.1111
p.D840N	TCGA-AX-A0J0	UCEC	TCGA	DSGPET	DEG_SCF_TRCP1_1	0.2222
p.D840N	DO41133	UCEC	ICGC	DSGPET	DEG_SCF_TRCP1_1	0.2222
p.D840Y	TCGA-B5-A0JY	UCEC	TCGA	DSGPET	DEG_SCF_TRCP1_1	0.2222
p.D840Y	DO43041	UCEC	ICGC	DSGPET	DEG_SCF_TRCP1_1	0.2222
p.D840E	TCGA-EL-A4K1	THCA	TCGA	DSGPET	DEG_SCF_TRCP1_1	0.2222
p.D840E	DO39102	THCA	ICGC	DSGPET	DEG_SCF_TRCP1_1	0.2222
p.P824L	SIDM00454	Rhabdomyosarcoma	GDSC	DSGPET	DEG_SCF_TRCP1_1	0.1389
p.P824L	SIDM01099	Neuroblastoma	GDSC	DSGPET	DEG_SCF_TRCP1_1	0.1389
p.P824L	SIDM00254	Neuroblastoma	GDSC	DSGPET	DEG_SCF_TRCP1_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N9B5	Junction-mediating and -regulatory protein	DEG_SCF_TRCP1_1	831:836	DSGPET	BTRC	0.7808	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons