DegronMD - Q8N9B5(JMY)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R843I	TCGA-44-2656	LUAD	TCGA	DSGPET	DEG_SCF_TRCP1_1	831:836	Mutation rewiring degron network	0.1389
p.R843I	DO26052	LUAD	ICGC	DSGPET	DEG_SCF_TRCP1_1	831:836	Mutation rewiring degron network	0.1389
p.P823L	TCGA-A4-8630	KIRP	TCGA	DSGPET	DEG_SCF_TRCP1_1	831:836	Mutation rewiring degron network	0.1111
p.P823L	DO44489	KIRP	ICGC	DSGPET	DEG_SCF_TRCP1_1	831:836	Mutation rewiring degron network	0.1111
p.N924T	TCGA-AG-A002	READ	TCGA	LPPFPD	LIG_APCC_ABBA_1	913:918	Mutation rewiring degron network	0.1667
p.D840N	TCGA-AX-A0J0	UCEC	TCGA	DSGPET	DEG_SCF_TRCP1_1	831:836	Mutation rewiring degron network	0.2222
p.D840N	DO41133	UCEC	ICGC	DSGPET	DEG_SCF_TRCP1_1	831:836	Mutation rewiring degron network	0.2222
p.D840Y	TCGA-B5-A0JY	UCEC	TCGA	DSGPET	DEG_SCF_TRCP1_1	831:836	Mutation rewiring degron network	0.2222
p.D840Y	DO43041	UCEC	ICGC	DSGPET	DEG_SCF_TRCP1_1	831:836	Mutation rewiring degron network	0.2222
p.M266I	TCGA-D1-A1NY	UCEC	TCGA	LPVFPE	LIG_APCC_ABBA_1	256:261	Mutation rewiring degron network	0.1944
p.M266I	DO42512	UCEC	ICGC	LPVFPE	LIG_APCC_ABBA_1	256:261	Mutation rewiring degron network	0.1944
p.K907R	TCGA-D1-A1NY	UCEC	TCGA	LPPFPD	LIG_APCC_ABBA_1	913:918	Mutation substituting flanking lysine	0.2778
p.K907R	DO42512	UCEC	ICGC	LPPFPD	LIG_APCC_ABBA_1	913:918	Mutation substituting flanking lysine	0.2778
p.D840E	TCGA-EL-A4K1	THCA	TCGA	DSGPET	DEG_SCF_TRCP1_1	831:836	Mutation rewiring degron network	0.2222
p.D840E	DO39102	THCA	ICGC	DSGPET	DEG_SCF_TRCP1_1	831:836	Mutation rewiring degron network	0.2222
p.R911Q	DO227549	COCA	ICGC	LPPFPD	LIG_APCC_ABBA_1	913:918	Mutation rewiring degron network	0.2778
p.V248L	DO50318	ESAD	ICGC	LPVFPE	LIG_APCC_ABBA_1	256:261	Mutation rewiring degron network	0.1111
p.D918V	DO234307	ESAD	ICGC	LPPFPD	LIG_APCC_ABBA_1	913:918	Mutation altering degron motif	0.7785
p.V258L	DO228974	LICA	ICGC	LPVFPE	LIG_APCC_ABBA_1	256:261	Mutation altering degron motif	0.5654
p.K907N	DO229035	LICA	ICGC	LPPFPD	LIG_APCC_ABBA_1	913:918	Mutation substituting flanking lysine	0.2778
p.E262K	DO222572	MELA	ICGC	LPVFPE	LIG_APCC_ABBA_1	256:261	Mutation rewiring degron network	0.3056
p.P917S	DO222731	MELA	ICGC	LPPFPD	LIG_APCC_ABBA_1	913:918	Mutation altering degron motif	0.5641
p.P254R	SIDM00614	Hepatocellular Carcinoma	GDSC	LPVFPE	LIG_APCC_ABBA_1	256:261	Mutation rewiring degron network	0.2778
p.P254R	ACH-000848	Liver Cancer	CCLE	LPVFPE	LIG_APCC_ABBA_1	256:261	Mutation rewiring degron network	0.2778
p.P254R	JHH-7	liver	COSMIC	LPVFPE	LIG_APCC_ABBA_1	256:261	Mutation rewiring degron network	0.2778
p.P824L	SIDM00454	Rhabdomyosarcoma	GDSC	DSGPET	DEG_SCF_TRCP1_1	831:836	Mutation rewiring degron network	0.1389
p.P824L	SIDM01099	Neuroblastoma	GDSC	DSGPET	DEG_SCF_TRCP1_1	831:836	Mutation rewiring degron network	0.1389
p.P824L	SIDM00254	Neuroblastoma	GDSC	DSGPET	DEG_SCF_TRCP1_1	831:836	Mutation rewiring degron network	0.1389
p.V258A	SIDM00590	Oral Cavity Carcinoma	GDSC	LPVFPE	LIG_APCC_ABBA_1	256:261	Mutation altering degron motif	0.6936
p.V258A	SIDM00397	Acute Myeloid Leukemia	GDSC	LPVFPE	LIG_APCC_ABBA_1	256:261	Mutation altering degron motif	0.6936
p.V258A	SIDM01378	Ovarian Carcinoma	GDSC	LPVFPE	LIG_APCC_ABBA_1	256:261	Mutation altering degron motif	0.6936
p.V258A	Set2	haematopoietic and lymphoid tissue	COSMIC	LPVFPE	LIG_APCC_ABBA_1	256:261	Mutation altering degron motif	0.6936
p.V258A	HSC-2	upper aerodigestive tract	COSMIC	LPVFPE	LIG_APCC_ABBA_1	256:261	Mutation altering degron motif	0.6936
p.N924S	SIDM00561	Other Blood Cancers	GDSC	LPPFPD	LIG_APCC_ABBA_1	913:918	Mutation rewiring degron network	0.1667
p.N924S	ACH-002274	Leukemia	CCLE	LPPFPD	LIG_APCC_ABBA_1	913:918	Mutation rewiring degron network	0.1667
p.N924S	MLMA	haematopoietic and lymphoid tissue	COSMIC	LPPFPD	LIG_APCC_ABBA_1	913:918	Mutation rewiring degron network	0.1667
p.P263H	SIDM01770	Gastric Carcinoma	GDSC	LPVFPE	LIG_APCC_ABBA_1	256:261	Mutation rewiring degron network	0.2778

Kaplan plot for JMY in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

JMY

UniProt ID: Q8N9B5

Entrez ID: 133746

Protein name: Junction-mediating and -regulatory protein

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for JMY in