DegronMD

Uniprot ID: Q8N9B5

Source protein: Junction-mediating and -regulatory protein

Source gene: JMY

Class: LIG_APCC_ABBA_1

Location: 913:918

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8809

ASA_SCORE: 92.25

COIL: 0.9657

CONS_SCORE: 0.6152

DSS_SCORE: 0.5093

HELIX: 0.0227

FCONS_SCORE: 1.0514

RIG_SCORE: 0.6987

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N924T	TCGA-AG-A002	READ	TCGA	LPPFPD	LIG_APCC_ABBA_1	0.1667
p.K907R	TCGA-D1-A1NY	UCEC	TCGA	LPPFPD	LIG_APCC_ABBA_1	0.2778
p.K907R	DO42512	UCEC	ICGC	LPPFPD	LIG_APCC_ABBA_1	0.2778
p.R911Q	DO227549	COCA	ICGC	LPPFPD	LIG_APCC_ABBA_1	0.2778
p.D918V	DO234307	ESAD	ICGC	LPPFPD	LIG_APCC_ABBA_1	0.7785
p.K907N	DO229035	LICA	ICGC	LPPFPD	LIG_APCC_ABBA_1	0.2778
p.P917S	DO222731	MELA	ICGC	LPPFPD	LIG_APCC_ABBA_1	0.5641
p.N924S	SIDM00561	Other Blood Cancers	GDSC	LPPFPD	LIG_APCC_ABBA_1	0.1667
p.N924S	ACH-002274	Leukemia	CCLE	LPPFPD	LIG_APCC_ABBA_1	0.1667
p.N924S	MLMA	haematopoietic_and_lymphoid_tissue	COSMIC	LPPFPD	LIG_APCC_ABBA_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P55001	Microfibrillar-associated protein 2	LIG_APCC_ABBA_1	26:31	LPPFPD	APC,CDC20,FZR1	0.9957	More...
Q8N9B5	Junction-mediating and -regulatory protein	LIG_APCC_ABBA_1	913:918	LPPFPD	APC,CDC20,FZR1	0.8809	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons