DegronMD

Uniprot ID: P55001

Source protein: Microfibrillar-associated protein 2

Source gene: MFAP2

Class: LIG_APCC_ABBA_1

Location: 26:31

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9957

ASA_SCORE: 69.6

COIL: 0.927

CONS_SCORE: 0.5794

DSS_SCORE: 0.3919

HELIX: 0.0358

FCONS_SCORE: 0.8076

RIG_SCORE: 0.7127

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P26S	SU-DHL-10	haematopoietic_and_lymphoid_tissue	COSMIC	LPPFPD	LIG_APCC_ABBA_1	0.6752
p.P27S	SIDM00389	B-Cell Non-Hodgkin's Lymphoma	GDSC	LPPFPD	LIG_APCC_ABBA_1	0.5641
p.P27S	SU-DHL-10	haematopoietic_and_lymphoid_tissue	COSMIC	LPPFPD	LIG_APCC_ABBA_1	0.5641
p.V33I	TCGA-UY-A9PF	BLCA	TCGA	LPPFPD	LIG_APCC_ABBA_1	0.2778
p.V33I	DO219044	BLCA	ICGC	LPPFPD	LIG_APCC_ABBA_1	0.2778
p.Q33P	DO228483	BRCA	ICGC	LPPFPD	LIG_APCC_ABBA_1	0.2778
p.Q33K	DO229041	LICA	ICGC	LPPFPD	LIG_APCC_ABBA_1	0.2778
p.L23P	TCGA-LG-A6GG	LIHC	TCGA	LPPFPD	LIG_APCC_ABBA_1	0.25
p.L23P	DO49699	LIHC	ICGC	LPPFPD	LIG_APCC_ABBA_1	0.25
p.Q34P	SIDM00251	Gastric Carcinoma	GDSC	LPPFPD	LIG_APCC_ABBA_1	0.25
p.Q34P	SIDM00609	Kidney Carcinoma	GDSC	LPPFPD	LIG_APCC_ABBA_1	0.25
p.Q34P	SIDM00167	Head and Neck Carcinoma	GDSC	LPPFPD	LIG_APCC_ABBA_1	0.25
p.H36Q	DO28773	OV	ICGC	LPPFPD	LIG_APCC_ABBA_1	0.1944
p.H37Q	TCGA-61-2613	OV	TCGA	LPPFPD	LIG_APCC_ABBA_1	0.1667
p.D39N	DO8842	COAD	ICGC	LPPFPD	LIG_APCC_ABBA_1	0.1111
p.D39E	DO18212	KIRC	ICGC	LPPFPD	LIG_APCC_ABBA_1	0.1111
p.D40N	TCGA-AZ-4315	COAD	TCGA	LPPFPD	LIG_APCC_ABBA_1	0.0833
p.D40E	TCGA-BP-5174	KIRC	TCGA	LPPFPD	LIG_APCC_ABBA_1	0.0833

Showing 1 to 18 of 18 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N9B5	Junction-mediating and -regulatory protein	LIG_APCC_ABBA_1	913:918	LPPFPD	APC,CDC20,FZR1	0.8809	More...
P55001	Microfibrillar-associated protein 2	LIG_APCC_ABBA_1	26:31	LPPFPD	APC,CDC20,FZR1	0.9957	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons