DegronMD - P55001(MFAP2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.H37Q	TCGA-61-2613	OV	TCGA	LPPFPD	LIG_APCC_ABBA_1	26:31	Mutation rewiring degron network	0.1667
p.D40N	TCGA-AZ-4315	COAD	TCGA	LPPFPD	LIG_APCC_ABBA_1	26:31	Mutation rewiring degron network	0.0833
p.D40E	TCGA-BP-5174	KIRC	TCGA	LPPFPD	LIG_APCC_ABBA_1	26:31	Mutation rewiring degron network	0.0833
p.P45Q	TCGA-D3-A3CE	SKCM	TCGA	VTPRPS	DEG_SCF_FBW7_1	53:58	Mutation rewiring degron network	0.1111
p.Q67K	TCGA-DA-A1I1	SKCM	TCGA	VTPRPS	DEG_SCF_FBW7_1	53:58	Mutation rewiring degron network	0.0833
p.S58F	TCGA-DA-A1IC	SKCM	TCGA	VTPRPS	DEG_SCF_FBW7_1	53:58	Mutation altering degron motif	0.7982
p.S58F	DO37430	SKCM	ICGC	VTPRPS	DEG_SCF_FBW7_1	53:58	Mutation altering degron motif	0.7982
p.P57S	TCGA-G4-6302	COAD	TCGA	VTPRPS	DEG_SCF_FBW7_1	53:58	Mutation altering degron motif	0.5641
p.L23P	TCGA-LG-A6GG	LIHC	TCGA	LPPFPD	LIG_APCC_ABBA_1	26:31	Mutation rewiring degron network	0.25
p.L23P	DO49699	LIHC	ICGC	LPPFPD	LIG_APCC_ABBA_1	26:31	Mutation rewiring degron network	0.25
p.V33I	TCGA-UY-A9PF	BLCA	TCGA	LPPFPD	LIG_APCC_ABBA_1	26:31	Mutation rewiring degron network	0.2778
p.V33I	DO219044	BLCA	ICGC	LPPFPD	LIG_APCC_ABBA_1	26:31	Mutation rewiring degron network	0.2778
p.Q33P	DO228483	BRCA	ICGC	LPPFPD	LIG_APCC_ABBA_1	26:31	Mutation rewiring degron network	0.2778
p.D39N	DO8842	COAD	ICGC	LPPFPD	LIG_APCC_ABBA_1	26:31	Mutation rewiring degron network	0.1111
p.P56S	DO8778	COAD	ICGC	VTPRPS	DEG_SCF_FBW7_1	53:58	Mutation altering degron motif	0.6752
p.D39E	DO18212	KIRC	ICGC	LPPFPD	LIG_APCC_ABBA_1	26:31	Mutation rewiring degron network	0.1111
p.Q33K	DO229041	LICA	ICGC	LPPFPD	LIG_APCC_ABBA_1	26:31	Mutation rewiring degron network	0.2778
p.H36Q	DO28773	OV	ICGC	LPPFPD	LIG_APCC_ABBA_1	26:31	Mutation rewiring degron network	0.1944
p.P44Q	DO37405	SKCM	ICGC	VTPRPS	DEG_SCF_FBW7_1	53:58	Mutation rewiring degron network	0.0833
p.Q66K	DO37966	SKCM	ICGC	VTPRPS	DEG_SCF_FBW7_1	53:58	Mutation rewiring degron network	0.1111
p.P27S	SIDM00389	B-Cell Non-Hodgkin's Lymphoma	GDSC	LPPFPD	LIG_APCC_ABBA_1	26:31	Mutation altering degron motif	0.5641
p.P27S	SU-DHL-10	haematopoietic and lymphoid tissue	COSMIC	LPPFPD	LIG_APCC_ABBA_1	26:31	Mutation altering degron motif	0.5641
p.Y48H	SIDM00933	Breast Carcinoma	GDSC	VTPRPS	DEG_SCF_FBW7_1	53:58	Mutation rewiring degron network	0.1944
p.Y48H	CAL-51	breast	COSMIC	VTPRPS	DEG_SCF_FBW7_1	53:58	Mutation rewiring degron network	0.1944
p.Q34P	SIDM00251	Gastric Carcinoma	GDSC	LPPFPD	LIG_APCC_ABBA_1	26:31	Mutation rewiring degron network	0.25
p.Q34P	SIDM00609	Kidney Carcinoma	GDSC	LPPFPD	LIG_APCC_ABBA_1	26:31	Mutation rewiring degron network	0.25
p.Q34P	SIDM00167	Head and Neck Carcinoma	GDSC	LPPFPD	LIG_APCC_ABBA_1	26:31	Mutation rewiring degron network	0.25
p.P26S	SU-DHL-10	haematopoietic and lymphoid tissue	COSMIC	LPPFPD	LIG_APCC_ABBA_1	26:31	Mutation altering degron motif	0.6752
p.Y47H	CAL-51	breast	COSMIC	VTPRPS	DEG_SCF_FBW7_1	53:58	Mutation rewiring degron network	0.1667

Kaplan plot for MFAP2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MFAP2

UniProt ID: P55001

Entrez ID: 4237

Protein name: Microfibrillar-associated protein 2 (MFAP-2) (Microfibril-associated glycoprotein 1) (MAGP) (MAGP-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MFAP2 in