DegronMD

Uniprot ID: P55001

Source protein: Microfibrillar-associated protein 2

Source gene: MFAP2

Class: DEG_SCF_FBW7_1

Location: 53:58

E3 ligase: FBXW7

DEGRON score: 0.9226

ASA_SCORE: 64.8167

COIL: 0.8832

CONS_SCORE: 0.4315

DSS_SCORE: 0.6927

HELIX: 0.0685

FCONS_SCORE: 0.6764

RIG_SCORE: 0.711

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P45Q	TCGA-D3-A3CE	SKCM	TCGA	VTPRPS	DEG_SCF_FBW7_1	0.1111
p.Q67K	TCGA-DA-A1I1	SKCM	TCGA	VTPRPS	DEG_SCF_FBW7_1	0.0833
p.S58F	TCGA-DA-A1IC	SKCM	TCGA	VTPRPS	DEG_SCF_FBW7_1	0.7982
p.S58F	DO37430	SKCM	ICGC	VTPRPS	DEG_SCF_FBW7_1	0.7982
p.P57S	TCGA-G4-6302	COAD	TCGA	VTPRPS	DEG_SCF_FBW7_1	0.5641
p.P56S	DO8778	COAD	ICGC	VTPRPS	DEG_SCF_FBW7_1	0.6752
p.P44Q	DO37405	SKCM	ICGC	VTPRPS	DEG_SCF_FBW7_1	0.0833
p.Q66K	DO37966	SKCM	ICGC	VTPRPS	DEG_SCF_FBW7_1	0.1111
p.Y48H	SIDM00933	Breast Carcinoma	GDSC	VTPRPS	DEG_SCF_FBW7_1	0.1944
p.Y48H	CAL-51	breast	COSMIC	VTPRPS	DEG_SCF_FBW7_1	0.1944
p.Y47H	CAL-51	breast	COSMIC	VTPRPS	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P55001	Microfibrillar-associated protein 2	DEG_SCF_FBW7_1	53:58	VTPRPS	FBXW7	0.9226	More...
A8MTL3	RING finger protein 212B	DEG_SCF_FBW7_1	161:166	VTPRPS	FBXW7	0.9805	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons