DegronMD

Uniprot ID: Q8N9B5

Source protein: Junction-mediating and -regulatory protein

Source gene: JMY

Class: LIG_APCC_ABBA_1

Location: 256:261

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7683

ASA_SCORE: 57.75

COIL: 0.9082

CONS_SCORE: 0.6202

DSS_SCORE: 0.2686

HELIX: 0.0317

FCONS_SCORE: 1.0511

RIG_SCORE: 0.771

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M266I	TCGA-D1-A1NY	UCEC	TCGA	LPVFPE	LIG_APCC_ABBA_1	0.1944
p.M266I	DO42512	UCEC	ICGC	LPVFPE	LIG_APCC_ABBA_1	0.1944
p.V248L	DO50318	ESAD	ICGC	LPVFPE	LIG_APCC_ABBA_1	0.1111
p.V258L	DO228974	LICA	ICGC	LPVFPE	LIG_APCC_ABBA_1	0.5654
p.E262K	DO222572	MELA	ICGC	LPVFPE	LIG_APCC_ABBA_1	0.3056
p.P254R	SIDM00614	Hepatocellular Carcinoma	GDSC	LPVFPE	LIG_APCC_ABBA_1	0.2778
p.P254R	ACH-000848	Liver Cancer	CCLE	LPVFPE	LIG_APCC_ABBA_1	0.2778
p.P254R	JHH-7	liver	COSMIC	LPVFPE	LIG_APCC_ABBA_1	0.2778
p.V258A	SIDM00590	Oral Cavity Carcinoma	GDSC	LPVFPE	LIG_APCC_ABBA_1	0.6936
p.V258A	SIDM00397	Acute Myeloid Leukemia	GDSC	LPVFPE	LIG_APCC_ABBA_1	0.6936
p.V258A	SIDM01378	Ovarian Carcinoma	GDSC	LPVFPE	LIG_APCC_ABBA_1	0.6936
p.V258A	Set2	haematopoietic_and_lymphoid_tissue	COSMIC	LPVFPE	LIG_APCC_ABBA_1	0.6936
p.V258A	HSC-2	upper_aerodigestive_tract	COSMIC	LPVFPE	LIG_APCC_ABBA_1	0.6936
p.P263H	SIDM01770	Gastric Carcinoma	GDSC	LPVFPE	LIG_APCC_ABBA_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N9B5	Junction-mediating and -regulatory protein	LIG_APCC_ABBA_1	256:261	LPVFPE	APC,CDC20,FZR1	0.7683	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons