DegronMD

Uniprot ID: O94827

Source protein: Pleckstrin homology domain-containing family G member 5

Source gene: PLEKHG5

Class: DEG_SCF_TRCP1_1

Location: 776:782

E3 ligase: BTRC

DEGRON score: 0.9805

ASA_SCORE: 76.8143

COIL: 0.9197

CONS_SCORE: 0.3836

DSS_SCORE: 0.6802

HELIX: 0.0537

FCONS_SCORE: 1.0233

RIG_SCORE: 0.6067

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E791K	TCGA-CN-6020	HNSC	TCGA	DSGPFSS	DEG_SCF_TRCP1_1	0.0833
p.E792D	TCGA-EE-A2MR	SKCM	TCGA	DSGPFSS	DEG_SCF_TRCP1_1	0.0556
p.T769M	DO49095	COAD	ICGC	DSGPFSS	DEG_SCF_TRCP1_1	0.1389
p.S790N	DO227996	COCA	ICGC	DSGPFSS	DEG_SCF_TRCP1_1	0.1111
p.Q783K	DO20853	KIRP	ICGC	DSGPFSS	DEG_SCF_TRCP1_1	0.3056
p.P779H	DO37450	SKCM	ICGC	DSGPFSS	DEG_SCF_TRCP1_1	0.6583
p.L770R	DO48174	UCEC	ICGC	DSGPFSS	DEG_SCF_TRCP1_1	0.1667
p.D783N	DO41871	UCEC	ICGC	DSGPFSS	DEG_SCF_TRCP1_1	0.3056
p.P773S	SIDM00327	Hodgkin's Lymphoma	GDSC	DSGPFSS	DEG_SCF_TRCP1_1	0.25
p.P773S	L-428	haematopoietic_and_lymphoid_tissue	COSMIC	DSGPFSS	DEG_SCF_TRCP1_1	0.25
p.P771S	ACH-000754	Lymphoma	CCLE	DSGPFSS	DEG_SCF_TRCP1_1	0.1944
p.P771S	L-428	haematopoietic_and_lymphoid_tissue	COSMIC	DSGPFSS	DEG_SCF_TRCP1_1	0.1944
p.M775V	201T	lung	COSMIC	DSGPFSS	DEG_SCF_TRCP1_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94827	Pleckstrin homology domain-containing family G member 5	DEG_SCF_TRCP1_1	776:782	DSGPFSS	BTRC	0.9805	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons