DegronMD - O94827(PLEKHG5)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G846V	TCGA-69-7974	LUAD	TCGA	ESPRVPSP	DEG_COP1_1	845:852	Mutation altering degron motif	0.7532
p.Q862K	TCGA-BQ-7049	KIRP	TCGA	ESPRVPSP	DEG_COP1_1	845:852	Mutation blocking phosphorylation signal	0.5
p.E791K	TCGA-CN-6020	HNSC	TCGA	DSGPFSS	DEG_SCF_TRCP1_1	776:782	Mutation rewiring degron network	0.0833
p.P858H	TCGA-D3-A1Q6	SKCM	TCGA	ESPRVPSP	DEG_COP1_1	845:852	Mutation rewiring degron network	0.1667
p.E792D	TCGA-EE-A2MR	SKCM	TCGA	DSGPFSS	DEG_SCF_TRCP1_1	776:782	Mutation rewiring degron network	0.0556
p.S851F	TCGA-EO-A22U	UCEC	TCGA	ESPRVPSP	DEG_COP1_1	845:852	Mutation altering degron motif	0.9093
p.L849R	TCGA-EY-A549	UCEC	TCGA	ESPRVPSP	DEG_COP1_1	845:852	Mutation altering degron motif	0.8428
p.T848M	TCGA-NH-A5IV	COAD	TCGA	ESPRVPSP	DEG_COP1_1	845:852	Mutation altering degron motif	0.7423
p.T848M	SIDM00286	Neuroblastoma	GDSC	ESPRVPSP	DEG_COP1_1	845:852	Mutation altering degron motif	0.7423
p.R860C	DO536	BLCA	ICGC	ESPRVPSP	DEG_COP1_1	845:852	Mutation rewiring degron network	0.1111
p.R860H	DO223732	CESC	ICGC	ESPRVPSP	DEG_COP1_1	845:852	Mutation rewiring degron network	0.1111
p.T769M	DO49095	COAD	ICGC	DSGPFSS	DEG_SCF_TRCP1_1	776:782	Mutation rewiring degron network	0.1389
p.S790N	DO227996	COCA	ICGC	DSGPFSS	DEG_SCF_TRCP1_1	776:782	Mutation rewiring degron network	0.1111
p.R848H	DO233854	GACA	ICGC	ESPRVPSP	DEG_COP1_1	845:852	Mutation altering degron motif	0.7133
p.R859C	DO219054	HNSC	ICGC	ESPRVPSP	DEG_COP1_1	845:852	Mutation rewiring degron network	0.1389
p.R859C	DO24596	LUAD	ICGC	ESPRVPSP	DEG_COP1_1	845:852	Mutation rewiring degron network	0.1389
p.R859C	DO37452	SKCM	ICGC	ESPRVPSP	DEG_COP1_1	845:852	Mutation rewiring degron network	0.1389
p.R859C	MOG-G-CCM	central nervous system	COSMIC	ESPRVPSP	DEG_COP1_1	845:852	Mutation rewiring degron network	0.1389
p.R859C	NCI-H630	large intestine	COSMIC	ESPRVPSP	DEG_COP1_1	845:852	Mutation rewiring degron network	0.1389
p.Q783K	DO20853	KIRP	ICGC	DSGPFSS	DEG_SCF_TRCP1_1	776:782	Mutation rewiring degron network	0.3056
p.P841H	DO229025	LICA	ICGC	ESPRVPSP	DEG_COP1_1	845:852	Mutation rewiring degron network	0.2222
p.P841T	DO229027	LICA	ICGC	ESPRVPSP	DEG_COP1_1	845:852	Mutation rewiring degron network	0.2222
p.P779H	DO37450	SKCM	ICGC	DSGPFSS	DEG_SCF_TRCP1_1	776:782	Mutation altering degron motif	0.6583
p.P841S	DO219784	UCEC	ICGC	ESPRVPSP	DEG_COP1_1	845:852	Mutation rewiring degron network	0.2222
p.L770R	DO48174	UCEC	ICGC	DSGPFSS	DEG_SCF_TRCP1_1	776:782	Mutation rewiring degron network	0.1667
p.R861H	DO43306	UCEC	ICGC	ESPRVPSP	DEG_COP1_1	845:852	Mutation rewiring degron network	0.0833
p.D783N	DO41871	UCEC	ICGC	DSGPFSS	DEG_SCF_TRCP1_1	776:782	Mutation rewiring degron network	0.3056
p.M840T	SIDM02021	Esophageal Carcinoma	GDSC	ESPRVPSP	DEG_COP1_1	845:852	Mutation rewiring degron network	0.1944
p.P773S	SIDM00327	Hodgkin's Lymphoma	GDSC	DSGPFSS	DEG_SCF_TRCP1_1	776:782	Mutation rewiring degron network	0.25
p.P773S	L-428	haematopoietic and lymphoid tissue	COSMIC	DSGPFSS	DEG_SCF_TRCP1_1	776:782	Mutation rewiring degron network	0.25
p.A839T	SIDM00537	Colorectal Carcinoma	GDSC	ESPRVPSP	DEG_COP1_1	845:852	Mutation rewiring degron network	0.1667
p.A839T	GP5d	large intestine	COSMIC	ESPRVPSP	DEG_COP1_1	845:852	Mutation rewiring degron network	0.1667
p.P771S	ACH-000754	Lymphoma	CCLE	DSGPFSS	DEG_SCF_TRCP1_1	776:782	Mutation rewiring degron network	0.1944
p.P771S	L-428	haematopoietic and lymphoid tissue	COSMIC	DSGPFSS	DEG_SCF_TRCP1_1	776:782	Mutation rewiring degron network	0.1944
p.T848A	LIM1215	large intestine	COSMIC	ESPRVPSP	DEG_COP1_1	845:852	Mutation altering degron motif	0.7139
p.M775V	201T	lung	COSMIC	DSGPFSS	DEG_SCF_TRCP1_1	776:782	Mutation rewiring degron network	0.3056
p.R842Q	ES3	bone	COSMIC	ESPRVPSP	DEG_COP1_1	845:852	Mutation rewiring degron network	0.25
p.A837T	GP5d	large intestine	COSMIC	ESPRVPSP	DEG_COP1_1	845:852	Mutation rewiring degron network	0.1111

Kaplan plot for PLEKHG5 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PLEKHG5

UniProt ID: O94827

Entrez ID: 57449

Protein name: Pleckstrin homology domain-containing family G member 5 (PH domain-containing family G member 5) (Guanine nucleotide exchange factor 720) (GEF720)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PLEKHG5 in