DegronMD

Uniprot ID: O94827

Source protein: Pleckstrin homology domain-containing family G member 5

Source gene: PLEKHG5

Class: DEG_COP1_1

Location: 845:852

E3 ligase: COP1

DEGRON score: 0.993

ASA_SCORE: 101.1625

COIL: 0.9734

CONS_SCORE: 0.4281

DSS_SCORE: 0.7028

HELIX: 0.0136

FCONS_SCORE: 1.0858

RIG_SCORE: 0.533

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G846V	TCGA-69-7974	LUAD	TCGA	ESPRVPSP	DEG_COP1_1	0.7532
p.Q862K	TCGA-BQ-7049	KIRP	TCGA	ESPRVPSP	DEG_COP1_1	0.5
p.P858H	TCGA-D3-A1Q6	SKCM	TCGA	ESPRVPSP	DEG_COP1_1	0.1667
p.S851F	TCGA-EO-A22U	UCEC	TCGA	ESPRVPSP	DEG_COP1_1	0.9093
p.L849R	TCGA-EY-A549	UCEC	TCGA	ESPRVPSP	DEG_COP1_1	0.8428
p.T848M	TCGA-NH-A5IV	COAD	TCGA	ESPRVPSP	DEG_COP1_1	0.7423
p.T848M	SIDM00286	Neuroblastoma	GDSC	ESPRVPSP	DEG_COP1_1	0.7423
p.R860C	DO536	BLCA	ICGC	ESPRVPSP	DEG_COP1_1	0.1111
p.R860H	DO223732	CESC	ICGC	ESPRVPSP	DEG_COP1_1	0.1111
p.R848H	DO233854	GACA	ICGC	ESPRVPSP	DEG_COP1_1	0.7133
p.R859C	DO219054	HNSC	ICGC	ESPRVPSP	DEG_COP1_1	0.1389
p.R859C	DO24596	LUAD	ICGC	ESPRVPSP	DEG_COP1_1	0.1389
p.R859C	DO37452	SKCM	ICGC	ESPRVPSP	DEG_COP1_1	0.1389
p.R859C	MOG-G-CCM	central_nervous_system	COSMIC	ESPRVPSP	DEG_COP1_1	0.1389
p.R859C	NCI-H630	large_intestine	COSMIC	ESPRVPSP	DEG_COP1_1	0.1389
p.P841H	DO229025	LICA	ICGC	ESPRVPSP	DEG_COP1_1	0.2222
p.P841T	DO229027	LICA	ICGC	ESPRVPSP	DEG_COP1_1	0.2222
p.P841S	DO219784	UCEC	ICGC	ESPRVPSP	DEG_COP1_1	0.2222
p.R861H	DO43306	UCEC	ICGC	ESPRVPSP	DEG_COP1_1	0.0833
p.M840T	SIDM02021	Esophageal Carcinoma	GDSC	ESPRVPSP	DEG_COP1_1	0.1944
p.A839T	SIDM00537	Colorectal Carcinoma	GDSC	ESPRVPSP	DEG_COP1_1	0.1667
p.A839T	GP5d	large_intestine	COSMIC	ESPRVPSP	DEG_COP1_1	0.1667
p.T848A	LIM1215	large_intestine	COSMIC	ESPRVPSP	DEG_COP1_1	0.7139
p.R842Q	ES3	bone	COSMIC	ESPRVPSP	DEG_COP1_1	0.25
p.A837T	GP5d	large_intestine	COSMIC	ESPRVPSP	DEG_COP1_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94827	Pleckstrin homology domain-containing family G member 5	DEG_COP1_1	845:852	ESPRVPSP	COP1	0.993	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons