DegronMD

Uniprot ID: Q8N4X5

Source protein: Actin filament-associated protein 1-like 2

Source gene: AFAP1L2

Class: DEG_SCF_TRCP1_1

Location: 575:581

E3 ligase: BTRC

DEGRON score: 0.986

ASA_SCORE: 73.1714

COIL: 0.9667

CONS_SCORE: 0.2907

DSS_SCORE: 0.6883

HELIX: 0.0149

FCONS_SCORE: 1.0045

RIG_SCORE: 0.4908

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A571T	TCGA-24-1425	OV	TCGA	DSGPGPT	DEG_SCF_TRCP1_1	0.2222
p.A571T	DO29840	OV	ICGC	DSGPGPT	DEG_SCF_TRCP1_1	0.2222
p.P582T	TCGA-55-8203	LUAD	TCGA	DSGPGPT	DEG_SCF_TRCP1_1	0.3056
p.E591Q	TCGA-FD-A6TF	BLCA	TCGA	DSGPGPT	DEG_SCF_TRCP1_1	0.0556
p.P580L	TCGA-GF-A6C9	SKCM	TCGA	DSGPGPT	DEG_SCF_TRCP1_1	0.6471
p.P580L	DO51254	SKCM	ICGC	DSGPGPT	DEG_SCF_TRCP1_1	0.6471
p.V568M	DO10550	COAD	ICGC	DSGPGPT	DEG_SCF_TRCP1_1	0.1389
p.N582T	DO233207	GACA	ICGC	DSGPGPT	DEG_SCF_TRCP1_1	0.3056
p.P570S	DO11854	GBM	ICGC	DSGPGPT	DEG_SCF_TRCP1_1	0.1944
p.R588Q	DO14160	HNSC	ICGC	DSGPGPT	DEG_SCF_TRCP1_1	0.25
p.A567E	DO229034	LICA	ICGC	DSGPGPT	DEG_SCF_TRCP1_1	0.1111
p.A567E	DO229041	LICA	ICGC	DSGPGPT	DEG_SCF_TRCP1_1	0.1111
p.A567E	DO224563	LUSC	ICGC	DSGPGPT	DEG_SCF_TRCP1_1	0.1111
p.P576L	DO25084	LUAD	ICGC	DSGPGPT	DEG_SCF_TRCP1_1	0.7582
p.S576P	SIDM00969	Ovarian Carcinoma	GDSC	DSGPGPT	DEG_SCF_TRCP1_1	0.6752
p.S576P	SIDM00454	Rhabdomyosarcoma	GDSC	DSGPGPT	DEG_SCF_TRCP1_1	0.6752
p.S576P	SIDM00654	Small Cell Lung Carcinoma	GDSC	DSGPGPT	DEG_SCF_TRCP1_1	0.6752
p.S576P	SIDM01099	Neuroblastoma	GDSC	DSGPGPT	DEG_SCF_TRCP1_1	0.6752
p.S576P	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	DSGPGPT	DEG_SCF_TRCP1_1	0.6752
p.S576P	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	DSGPGPT	DEG_SCF_TRCP1_1	0.6752
p.S576P	SIDM00875	Breast Carcinoma	GDSC	DSGPGPT	DEG_SCF_TRCP1_1	0.6752
p.S576P	SIDM00309	Mesothelioma	GDSC	DSGPGPT	DEG_SCF_TRCP1_1	0.6752
p.S576P	SIDM00032	Bladder Carcinoma	GDSC	DSGPGPT	DEG_SCF_TRCP1_1	0.6752
p.S576P	SIDM01147	Gastric Carcinoma	GDSC	DSGPGPT	DEG_SCF_TRCP1_1	0.6752
p.S576P	SIDM01133	Other Solid Cancers	GDSC	DSGPGPT	DEG_SCF_TRCP1_1	0.6752
p.S576P	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	DSGPGPT	DEG_SCF_TRCP1_1	0.6752
p.S576P	SIDM00431	T-Lymphoblastic Leukemia	GDSC	DSGPGPT	DEG_SCF_TRCP1_1	0.6752
p.S576P	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	DSGPGPT	DEG_SCF_TRCP1_1	0.6752
p.S576P	SIDM00785	Acute Myeloid Leukemia	GDSC	DSGPGPT	DEG_SCF_TRCP1_1	0.6752
p.S576P	SIDM01752	Pancreatic Carcinoma	GDSC	DSGPGPT	DEG_SCF_TRCP1_1	0.6752
p.E584K	SIDM00528	Breast Carcinoma	GDSC	DSGPGPT	DEG_SCF_TRCP1_1	0.25
p.E584K	ACH-000934	Breast Cancer	CCLE	DSGPGPT	DEG_SCF_TRCP1_1	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSGPGPT

Degron related mutations and impact score

Drug responses associated with AFAP1L2 mutations

All proteins holding degron of DSGPGPT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N4X5	Actin filament-associated protein 1-like 2	DEG_SCF_TRCP1_1	575:581	DSGPGPT	BTRC	0.986	More...