DegronMD - Q8N4X5(AFAP1L2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A571T	TCGA-24-1425	OV	TCGA	DSGPGPT	DEG_SCF_TRCP1_1	575:581	Mutation rewiring degron network	0.2222
p.A571T	DO29840	OV	ICGC	DSGPGPT	DEG_SCF_TRCP1_1	575:581	Mutation rewiring degron network	0.2222
p.S777F	TCGA-44-5643	LUAD	TCGA	PDCTPVNS	DEG_SCF_FBW7_1	779:786	Mutation rewiring degron network	0.2778
p.P582T	TCGA-55-8203	LUAD	TCGA	DSGPGPT	DEG_SCF_TRCP1_1	575:581	Mutation rewiring degron network	0.3056
p.R535Q	TCGA-CV-7568	HNSC	TCGA	LDLTPVKS	DEG_SCF_FBW7_1	538:545	Mutation rewiring degron network	0.25
p.R535Q	TCGA-CV-7568	HNSC	TCGA	YLDLTPVK	DEG_SCF_SKP2-CKS1_1	537:544	Mutation rewiring degron network	0.2778
p.R535Q	SIDM01943	Colorectal Carcinoma	GDSC	LDLTPVKS	DEG_SCF_FBW7_1	538:545	Mutation rewiring degron network	0.25
p.R535Q	SIDM01943	Colorectal Carcinoma	GDSC	YLDLTPVK	DEG_SCF_SKP2-CKS1_1	537:544	Mutation rewiring degron network	0.2778
p.P550S	TCGA-EA-A3HQ	CESC	TCGA	LDLTPVKS	DEG_SCF_FBW7_1	538:545	Mutation rewiring degron network	0.1944
p.P550S	TCGA-EA-A3HQ	CESC	TCGA	YLDLTPVK	DEG_SCF_SKP2-CKS1_1	537:544	Mutation rewiring degron network	0.1667
p.P550S	DO6317	CESC	ICGC	LDLTPVKS	DEG_SCF_FBW7_1	538:545	Mutation rewiring degron network	0.1944
p.P550S	DO6317	CESC	ICGC	YLDLTPVK	DEG_SCF_SKP2-CKS1_1	537:544	Mutation rewiring degron network	0.1667
p.S796L	TCGA-EE-A2GP	SKCM	TCGA	PDCTPVNS	DEG_SCF_FBW7_1	779:786	Mutation blocking phosphorylation signal	0.5
p.S796L	DO37422	SKCM	ICGC	PDCTPVNS	DEG_SCF_FBW7_1	779:786	Mutation blocking phosphorylation signal	0.5
p.S796L	ACH-001200	Rhabdoid	CCLE	PDCTPVNS	DEG_SCF_FBW7_1	779:786	Mutation blocking phosphorylation signal	0.5
p.E591Q	TCGA-FD-A6TF	BLCA	TCGA	DSGPGPT	DEG_SCF_TRCP1_1	575:581	Mutation rewiring degron network	0.0556
p.P580L	TCGA-GF-A6C9	SKCM	TCGA	DSGPGPT	DEG_SCF_TRCP1_1	575:581	Mutation altering degron motif	0.6471
p.P580L	DO51254	SKCM	ICGC	DSGPGPT	DEG_SCF_TRCP1_1	575:581	Mutation altering degron motif	0.6471
p.E774V	DO44045	BLCA	ICGC	PDCTPVNS	DEG_SCF_FBW7_1	779:786	Mutation blocking phosphorylation signal	0.6389
p.V568M	DO10550	COAD	ICGC	DSGPGPT	DEG_SCF_TRCP1_1	575:581	Mutation rewiring degron network	0.1389
p.N582T	DO233207	GACA	ICGC	DSGPGPT	DEG_SCF_TRCP1_1	575:581	Mutation rewiring degron network	0.3056
p.R777W	DO233652	GACA	ICGC	PDCTPVNS	DEG_SCF_FBW7_1	779:786	Mutation rewiring degron network	0.2778
p.P570S	DO11854	GBM	ICGC	DSGPGPT	DEG_SCF_TRCP1_1	575:581	Mutation rewiring degron network	0.1944
p.R588Q	DO14160	HNSC	ICGC	DSGPGPT	DEG_SCF_TRCP1_1	575:581	Mutation substituting flanking lysine	0.25
p.R783C	DO19380	KIRC	ICGC	PDCTPVNS	DEG_SCF_FBW7_1	779:786	Mutation altering degron motif	0.8301
p.N792K	DO228952	LICA	ICGC	PDCTPVNS	DEG_SCF_FBW7_1	779:786	Mutation rewiring degron network	0.1667
p.H548N	DO228974	LICA	ICGC	LDLTPVKS	DEG_SCF_FBW7_1	538:545	Mutation rewiring degron network	0.25
p.H548N	DO228974	LICA	ICGC	YLDLTPVK	DEG_SCF_SKP2-CKS1_1	537:544	Mutation rewiring degron network	0.2222
p.A567E	DO229034	LICA	ICGC	DSGPGPT	DEG_SCF_TRCP1_1	575:581	Mutation rewiring degron network	0.1111
p.A567E	DO229041	LICA	ICGC	DSGPGPT	DEG_SCF_TRCP1_1	575:581	Mutation rewiring degron network	0.1111
p.A567E	DO224563	LUSC	ICGC	DSGPGPT	DEG_SCF_TRCP1_1	575:581	Mutation rewiring degron network	0.1111
p.D795E	DO229009	LICA	ICGC	PDCTPVNS	DEG_SCF_FBW7_1	779:786	Mutation rewiring degron network	0.0833
p.P576L	DO25084	LUAD	ICGC	DSGPGPT	DEG_SCF_TRCP1_1	575:581	Mutation altering degron motif	0.7582
p.R551C	DO47317	SKCM	ICGC	LDLTPVKS	DEG_SCF_FBW7_1	538:545	Mutation rewiring degron network	0.1667
p.R551C	DO47317	SKCM	ICGC	YLDLTPVK	DEG_SCF_SKP2-CKS1_1	537:544	Mutation rewiring degron network	0.1389
p.S576P	SIDM00969	Ovarian Carcinoma	GDSC	DSGPGPT	DEG_SCF_TRCP1_1	575:581	Mutation altering degron motif	0.6752
p.S576P	SIDM00454	Rhabdomyosarcoma	GDSC	DSGPGPT	DEG_SCF_TRCP1_1	575:581	Mutation altering degron motif	0.6752
p.S576P	SIDM00654	Small Cell Lung Carcinoma	GDSC	DSGPGPT	DEG_SCF_TRCP1_1	575:581	Mutation altering degron motif	0.6752
p.S576P	SIDM01099	Neuroblastoma	GDSC	DSGPGPT	DEG_SCF_TRCP1_1	575:581	Mutation altering degron motif	0.6752
p.S576P	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	DSGPGPT	DEG_SCF_TRCP1_1	575:581	Mutation altering degron motif	0.6752
p.S576P	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	DSGPGPT	DEG_SCF_TRCP1_1	575:581	Mutation altering degron motif	0.6752
p.S576P	SIDM00875	Breast Carcinoma	GDSC	DSGPGPT	DEG_SCF_TRCP1_1	575:581	Mutation altering degron motif	0.6752
p.S576P	SIDM00309	Mesothelioma	GDSC	DSGPGPT	DEG_SCF_TRCP1_1	575:581	Mutation altering degron motif	0.6752
p.S576P	SIDM00032	Bladder Carcinoma	GDSC	DSGPGPT	DEG_SCF_TRCP1_1	575:581	Mutation altering degron motif	0.6752
p.S576P	SIDM01147	Gastric Carcinoma	GDSC	DSGPGPT	DEG_SCF_TRCP1_1	575:581	Mutation altering degron motif	0.6752
p.S576P	SIDM01133	Other Solid Cancers	GDSC	DSGPGPT	DEG_SCF_TRCP1_1	575:581	Mutation altering degron motif	0.6752
p.S576P	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	DSGPGPT	DEG_SCF_TRCP1_1	575:581	Mutation altering degron motif	0.6752
p.S576P	SIDM00431	T-Lymphoblastic Leukemia	GDSC	DSGPGPT	DEG_SCF_TRCP1_1	575:581	Mutation altering degron motif	0.6752
p.S576P	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	DSGPGPT	DEG_SCF_TRCP1_1	575:581	Mutation altering degron motif	0.6752
p.S576P	SIDM00785	Acute Myeloid Leukemia	GDSC	DSGPGPT	DEG_SCF_TRCP1_1	575:581	Mutation altering degron motif	0.6752
p.S576P	SIDM01752	Pancreatic Carcinoma	GDSC	DSGPGPT	DEG_SCF_TRCP1_1	575:581	Mutation altering degron motif	0.6752
p.A772V	SIDM00930	Osteosarcoma	GDSC	PDCTPVNS	DEG_SCF_FBW7_1	779:786	Mutation rewiring degron network	0.1389
p.A772V	ACH-001715	Bone Cancer	CCLE	PDCTPVNS	DEG_SCF_FBW7_1	779:786	Mutation rewiring degron network	0.1389
p.T788I	SIDM00688	B-Cell Non-Hodgkin's Lymphoma	GDSC	PDCTPVNS	DEG_SCF_FBW7_1	779:786	Mutation blocking phosphorylation signal	0.7222
p.T788I	ACH-002253	Lymphoma	CCLE	PDCTPVNS	DEG_SCF_FBW7_1	779:786	Mutation blocking phosphorylation signal	0.7222
p.T788I	JSC-1	haematopoietic and lymphoid tissue	COSMIC	PDCTPVNS	DEG_SCF_FBW7_1	779:786	Mutation blocking phosphorylation signal	0.7222
p.E584K	SIDM00528	Breast Carcinoma	GDSC	DSGPGPT	DEG_SCF_TRCP1_1	575:581	Mutation rewiring degron network	0.25
p.E584K	ACH-000934	Breast Cancer	CCLE	DSGPGPT	DEG_SCF_TRCP1_1	575:581	Mutation rewiring degron network	0.25
p.R769H	SIDM01018	Hodgkin's Lymphoma	GDSC	PDCTPVNS	DEG_SCF_FBW7_1	779:786	Mutation rewiring degron network	0.0556
p.R769H	KM-H2	haematopoietic and lymphoid tissue	COSMIC	PDCTPVNS	DEG_SCF_FBW7_1	779:786	Mutation rewiring degron network	0.0556
p.T789A	SIDM01588	Endometrial Carcinoma	GDSC	PDCTPVNS	DEG_SCF_FBW7_1	779:786	Mutation rewiring degron network	0.25
p.T789A	ACH-000993	Endometrial/Uterine Cancer	CCLE	PDCTPVNS	DEG_SCF_FBW7_1	779:786	Mutation rewiring degron network	0.25
p.R769S	CAL-148	breast	COSMIC	PDCTPVNS	DEG_SCF_FBW7_1	779:786	Mutation rewiring degron network	0.0556
p.T784I	JSC-1	haematopoietic and lymphoid tissue	COSMIC	PDCTPVNS	DEG_SCF_FBW7_1	779:786	Mutation altering degron motif	0.7078

DegronMD: protein-targeted degradation, mutation and drug response to degrons

AFAP1L2

UniProt ID: Q8N4X5

Entrez ID: 84632

Protein name: Actin filament-associated protein 1-like 2 (AFAP1-like protein 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for AFAP1L2 in