DegronMD

Uniprot ID: Q8N4X5

Source protein: Actin filament-associated protein 1-like 2

Source gene: AFAP1L2

Class: DEG_SCF_SKP2-CKS1_1

Location: 537:544

E3 ligase: SKP2,CSK1

DEGRON score: 0.9994

ASA_SCORE: 76.1875

COIL: 0.761

CONS_SCORE: 0.4738

DSS_SCORE: 0.4794

HELIX: 0.1648

FCONS_SCORE: 1.3693

RIG_SCORE: 0.7836

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R535Q	TCGA-CV-7568	HNSC	TCGA	YLDLTPVK	DEG_SCF_SKP2-CKS1_1	0.2778
p.R535Q	SIDM01943	Colorectal Carcinoma	GDSC	YLDLTPVK	DEG_SCF_SKP2-CKS1_1	0.2778
p.P550S	TCGA-EA-A3HQ	CESC	TCGA	YLDLTPVK	DEG_SCF_SKP2-CKS1_1	0.1667
p.P550S	DO6317	CESC	ICGC	YLDLTPVK	DEG_SCF_SKP2-CKS1_1	0.1667
p.H548N	DO228974	LICA	ICGC	YLDLTPVK	DEG_SCF_SKP2-CKS1_1	0.2222
p.R551C	DO47317	SKCM	ICGC	YLDLTPVK	DEG_SCF_SKP2-CKS1_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N4X5	Actin filament-associated protein 1-like 2	DEG_SCF_SKP2-CKS1_1	537:544	YLDLTPVK	SKP2,CSK1	0.9994	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons