DegronMD

Uniprot ID: Q8N4X5

Source protein: Actin filament-associated protein 1-like 2

Source gene: AFAP1L2

Class: DEG_SCF_FBW7_1

Location: 538:545

E3 ligase: FBXW7

DEGRON score: 0.9993

ASA_SCORE: 73.15

COIL: 0.769

CONS_SCORE: 0.4857

DSS_SCORE: 0.4668

HELIX: 0.1589

FCONS_SCORE: 1.4176

RIG_SCORE: 0.7749

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R535Q	TCGA-CV-7568	HNSC	TCGA	LDLTPVKS	DEG_SCF_FBW7_1	0.25
p.R535Q	SIDM01943	Colorectal Carcinoma	GDSC	LDLTPVKS	DEG_SCF_FBW7_1	0.25
p.P550S	TCGA-EA-A3HQ	CESC	TCGA	LDLTPVKS	DEG_SCF_FBW7_1	0.1944
p.P550S	DO6317	CESC	ICGC	LDLTPVKS	DEG_SCF_FBW7_1	0.1944
p.H548N	DO228974	LICA	ICGC	LDLTPVKS	DEG_SCF_FBW7_1	0.25
p.R551C	DO47317	SKCM	ICGC	LDLTPVKS	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N4X5	Actin filament-associated protein 1-like 2	DEG_SCF_FBW7_1	538:545	LDLTPVKS	FBXW7	0.9993	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons