DegronMD

Uniprot ID: Q8N4X5

Source protein: Actin filament-associated protein 1-like 2

Source gene: AFAP1L2

Class: DEG_SCF_FBW7_1

Location: 779:786

E3 ligase: FBXW7

DEGRON score: 0.9998

ASA_SCORE: 63.2625

COIL: 0.7176

CONS_SCORE: 0.4577

DSS_SCORE: 0.5185

HELIX: 0.1458

FCONS_SCORE: 1.0943

RIG_SCORE: 0.7244

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S777F	TCGA-44-5643	LUAD	TCGA	PDCTPVNS	DEG_SCF_FBW7_1	0.2778
p.S796L	TCGA-EE-A2GP	SKCM	TCGA	PDCTPVNS	DEG_SCF_FBW7_1	0.5
p.S796L	DO37422	SKCM	ICGC	PDCTPVNS	DEG_SCF_FBW7_1	0.5
p.S796L	ACH-001200	Rhabdoid	CCLE	PDCTPVNS	DEG_SCF_FBW7_1	0.5
p.E774V	DO44045	BLCA	ICGC	PDCTPVNS	DEG_SCF_FBW7_1	0.6389
p.R777W	DO233652	GACA	ICGC	PDCTPVNS	DEG_SCF_FBW7_1	0.2778
p.R783C	DO19380	KIRC	ICGC	PDCTPVNS	DEG_SCF_FBW7_1	0.8301
p.N792K	DO228952	LICA	ICGC	PDCTPVNS	DEG_SCF_FBW7_1	0.1667
p.D795E	DO229009	LICA	ICGC	PDCTPVNS	DEG_SCF_FBW7_1	0.0833
p.A772V	SIDM00930	Osteosarcoma	GDSC	PDCTPVNS	DEG_SCF_FBW7_1	0.1389
p.A772V	ACH-001715	Bone Cancer	CCLE	PDCTPVNS	DEG_SCF_FBW7_1	0.1389
p.T788I	SIDM00688	B-Cell Non-Hodgkin's Lymphoma	GDSC	PDCTPVNS	DEG_SCF_FBW7_1	0.7222
p.T788I	ACH-002253	Lymphoma	CCLE	PDCTPVNS	DEG_SCF_FBW7_1	0.7222
p.T788I	JSC-1	haematopoietic_and_lymphoid_tissue	COSMIC	PDCTPVNS	DEG_SCF_FBW7_1	0.7222
p.R769H	SIDM01018	Hodgkin's Lymphoma	GDSC	PDCTPVNS	DEG_SCF_FBW7_1	0.0556
p.R769H	KM-H2	haematopoietic_and_lymphoid_tissue	COSMIC	PDCTPVNS	DEG_SCF_FBW7_1	0.0556
p.T789A	SIDM01588	Endometrial Carcinoma	GDSC	PDCTPVNS	DEG_SCF_FBW7_1	0.25
p.T789A	ACH-000993	Endometrial/Uterine Cancer	CCLE	PDCTPVNS	DEG_SCF_FBW7_1	0.25
p.R769S	CAL-148	breast	COSMIC	PDCTPVNS	DEG_SCF_FBW7_1	0.0556
p.T784I	JSC-1	haematopoietic_and_lymphoid_tissue	COSMIC	PDCTPVNS	DEG_SCF_FBW7_1	0.7078

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N4X5	Actin filament-associated protein 1-like 2	DEG_SCF_FBW7_1	779:786	PDCTPVNS	FBXW7	0.9998	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons