DegronMD

Uniprot ID: Q7L2E3

Source protein: ATP-dependent RNA helicase DHX30

Source gene: DHX30

Class: DEG_SCF_TRCP1_1

Location: 389:394

E3 ligase: BTRC

DEGRON score: 0.7426

ASA_SCORE: 65.7167

COIL: 0.8408

CONS_SCORE: 0.3363

DSS_SCORE: 0.4775

HELIX: 0.0332

FCONS_SCORE: 0.9435

RIG_SCORE: 0.6123

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D381N	TCGA-86-7713	LUAD	TCGA	DSGPLS	DEG_SCF_TRCP1_1	0.1111
p.G399D	TCGA-AX-A0J1	UCEC	TCGA	DSGPLS	DEG_SCF_TRCP1_1	0.1944
p.D395N	TCGA-DD-AADE	LIHC	TCGA	DSGPLS	DEG_SCF_TRCP1_1	0.3056
p.Q379H	TCGA-FJ-A3Z7	BLCA	TCGA	DSGPLS	DEG_SCF_TRCP1_1	0.0556
p.A401T	DO223732	CESC	ICGC	DSGPLS	DEG_SCF_TRCP1_1	0.1389
p.A401T	DO10324	COAD	ICGC	DSGPLS	DEG_SCF_TRCP1_1	0.1389
p.A401T	DO41361	UCEC	ICGC	DSGPLS	DEG_SCF_TRCP1_1	0.1389
p.E391Q	DO24712	LUAD	ICGC	DSGPLS	DEG_SCF_TRCP1_1	0.6744
p.R394W	DO47873	STAD	ICGC	DSGPLS	DEG_SCF_TRCP1_1	0.8634
p.R394W	DO41235	UCEC	ICGC	DSGPLS	DEG_SCF_TRCP1_1	0.8634
p.D402G	DO38192	STAD	ICGC	DSGPLS	DEG_SCF_TRCP1_1	0.1111
p.R384C	DO42320	UCEC	ICGC	DSGPLS	DEG_SCF_TRCP1_1	0.1944
p.D381H	SIDM00628	Breast Carcinoma	GDSC	DSGPLS	DEG_SCF_TRCP1_1	0.1111
p.D381H	MDA-MB-468	breast	COSMIC	DSGPLS	DEG_SCF_TRCP1_1	0.1111
p.R384H	ACH-002048	Sarcoma	CCLE	DSGPLS	DEG_SCF_TRCP1_1	0.1944
p.R384H	SNU-1040	large_intestine	COSMIC	DSGPLS	DEG_SCF_TRCP1_1	0.1944
p.V383A	ACH-002256	Leukemia	CCLE	DSGPLS	DEG_SCF_TRCP1_1	0.1667
p.V383A	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	DSGPLS	DEG_SCF_TRCP1_1	0.1667
p.V383I	YT	haematopoietic_and_lymphoid_tissue	COSMIC	DSGPLS	DEG_SCF_TRCP1_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7L2E3	ATP-dependent RNA helicase DHX30	DEG_SCF_TRCP1_1	389:394	DSGPLS	BTRC	0.7426	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons