DegronMD - Q7L2E3(DHX30)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D45Y	TCGA-69-7974	LUAD	TCGA	VNPTPGGT	DEG_SCF_FBW7_1	31:38	Mutation rewiring degron network	0.1389
p.D381N	TCGA-86-7713	LUAD	TCGA	DSGPLS	DEG_SCF_TRCP1_1	389:394	Mutation rewiring degron network	0.1111
p.S43A	TCGA-AA-3675	COAD	TCGA	VNPTPGGT	DEG_SCF_FBW7_1	31:38	Mutation rewiring degron network	0.1944
p.V1135M	TCGA-AA-A022	COAD	TCGA	LRRALGRMV	DEG_APCC_DBOX_1	1141:1149	Mutation rewiring degron network	0.1667
p.G399D	TCGA-AX-A0J1	UCEC	TCGA	DSGPLS	DEG_SCF_TRCP1_1	389:394	Mutation rewiring degron network	0.1944
p.R1147C	TCGA-B5-A3FC	UCEC	TCGA	LRRALGRMV	DEG_APCC_DBOX_1	1141:1149	Mutation altering degron motif	0.719
p.L47F	TCGA-CA-6717	COAD	TCGA	VNPTPGGT	DEG_SCF_FBW7_1	31:38	Mutation rewiring degron network	0.0833
p.R44S	TCGA-D3-A2JP	SKCM	TCGA	VNPTPGGT	DEG_SCF_FBW7_1	31:38	Mutation rewiring degron network	0.1667
p.D395N	TCGA-DD-AADE	LIHC	TCGA	DSGPLS	DEG_SCF_TRCP1_1	389:394	Mutation rewiring degron network	0.3056
p.P22L	TCGA-DF-A2KS	UCEC	TCGA	VNPTPGGT	DEG_SCF_FBW7_1	31:38	Mutation rewiring degron network	0.0833
p.P22L	DO223285	UCEC	ICGC	VNPTPGGT	DEG_SCF_FBW7_1	31:38	Mutation rewiring degron network	0.0833
p.E1167Q	TCGA-DU-A5TT	LGG	TCGA	LRSELAALP	DEG_APCC_DBOX_1	1153:1161	Mutation rewiring degron network	0.1667
p.P22S	TCGA-EE-A2MU	SKCM	TCGA	VNPTPGGT	DEG_SCF_FBW7_1	31:38	Mutation rewiring degron network	0.0833
p.P22S	DO37436	SKCM	ICGC	VNPTPGGT	DEG_SCF_FBW7_1	31:38	Mutation rewiring degron network	0.0833
p.Q379H	TCGA-FJ-A3Z7	BLCA	TCGA	DSGPLS	DEG_SCF_TRCP1_1	389:394	Mutation rewiring degron network	0.0556
p.R1142W	TCGA-IB-7651	PAAD	TCGA	LRRALGRMV	DEG_APCC_DBOX_1	1141:1149	Mutation altering degron motif	0.8634
p.R1154C	TCGA-IB-7651	PAAD	TCGA	LRSELAALP	DEG_APCC_DBOX_1	1153:1161	Mutation altering degron motif	0.8301
p.R1154C	ACH-002287	Colon/Colorectal Cancer	CCLE	LRSELAALP	DEG_APCC_DBOX_1	1153:1161	Mutation altering degron motif	0.8301
p.R1154C	NCI-H630	large intestine	COSMIC	LRSELAALP	DEG_APCC_DBOX_1	1153:1161	Mutation altering degron motif	0.8301
p.R1133H	TCGA-XK-AAIW	PRAD	TCGA	LRRALGRMV	DEG_APCC_DBOX_1	1141:1149	Mutation rewiring degron network	0.1111
p.R24T	DO219033	BLCA	ICGC	VNPTPGGT	DEG_SCF_FBW7_1	31:38	Mutation rewiring degron network	0.1389
p.R25H	DO228430	BRCA	ICGC	VNPTPGGT	DEG_SCF_FBW7_1	31:38	Mutation rewiring degron network	0.1667
p.R25H	DO227979	COCA	ICGC	VNPTPGGT	DEG_SCF_FBW7_1	31:38	Mutation rewiring degron network	0.1667
p.A401T	DO223732	CESC	ICGC	DSGPLS	DEG_SCF_TRCP1_1	389:394	Mutation rewiring degron network	0.1389
p.A401T	DO10324	COAD	ICGC	DSGPLS	DEG_SCF_TRCP1_1	389:394	Mutation rewiring degron network	0.1389
p.A401T	DO41361	UCEC	ICGC	DSGPLS	DEG_SCF_TRCP1_1	389:394	Mutation rewiring degron network	0.1389
p.P22H	DO233215	GACA	ICGC	VNPTPGGT	DEG_SCF_FBW7_1	31:38	Mutation rewiring degron network	0.0833
p.E1139Q	DO44564	LGG	ICGC	LRRALGRMV	DEG_APCC_DBOX_1	1141:1149	Mutation blocking ubiquitination signal	0.7222
p.V36F	DO229006	LICA	ICGC	VNPTPGGT	DEG_SCF_FBW7_1	31:38	Mutation altering degron motif	0.7068
p.K32E	DO44634	LICA	ICGC	VNPTPGGT	DEG_SCF_FBW7_1	31:38	Mutation altering degron motif	0.7022
p.E391Q	DO24712	LUAD	ICGC	DSGPLS	DEG_SCF_TRCP1_1	389:394	Mutation altering degron motif	0.6744
p.A1145V	DO228138	PBCA	ICGC	LRRALGRMV	DEG_APCC_DBOX_1	1141:1149	Mutation altering degron motif	0.6936
p.R394W	DO47873	STAD	ICGC	DSGPLS	DEG_SCF_TRCP1_1	389:394	Mutation altering degron motif	0.8634
p.R394W	DO41235	UCEC	ICGC	DSGPLS	DEG_SCF_TRCP1_1	389:394	Mutation altering degron motif	0.8634
p.K32N	DO47743	STAD	ICGC	VNPTPGGT	DEG_SCF_FBW7_1	31:38	Mutation altering degron motif	0.6918
p.D402G	DO38192	STAD	ICGC	DSGPLS	DEG_SCF_TRCP1_1	389:394	Mutation rewiring degron network	0.1111
p.R384C	DO42320	UCEC	ICGC	DSGPLS	DEG_SCF_TRCP1_1	389:394	Mutation rewiring degron network	0.1944
p.R1151Q	SIDM01954	Colorectal Carcinoma	GDSC	LRRALGRMV	DEG_APCC_DBOX_1	1141:1149	Mutation rewiring degron network	0.2778
p.R1151Q	SIDM01954	Colorectal Carcinoma	GDSC	LRSELAALP	DEG_APCC_DBOX_1	1153:1161	Mutation rewiring degron network	0.2778
p.L26I	SIDM02021	Esophageal Carcinoma	GDSC	VNPTPGGT	DEG_SCF_FBW7_1	31:38	Mutation rewiring degron network	0.1944
p.P24H	SIDM00683	Prostate Carcinoma	GDSC	VNPTPGGT	DEG_SCF_FBW7_1	31:38	Mutation rewiring degron network	0.1389
p.P24H	LNCaP-Clone-FGC	prostate	COSMIC	VNPTPGGT	DEG_SCF_FBW7_1	31:38	Mutation rewiring degron network	0.1389
p.P22A	SIDM00516	Melanoma	GDSC	VNPTPGGT	DEG_SCF_FBW7_1	31:38	Mutation rewiring degron network	0.0833
p.P22A	ACH-002166	Skin Cancer	CCLE	VNPTPGGT	DEG_SCF_FBW7_1	31:38	Mutation rewiring degron network	0.0833
p.P22A	MZ7-mel	skin	COSMIC	VNPTPGGT	DEG_SCF_FBW7_1	31:38	Mutation rewiring degron network	0.0833
p.T34A	SIDM00839	Colorectal Carcinoma	GDSC	VNPTPGGT	DEG_SCF_FBW7_1	31:38	Mutation altering degron motif	0.7139
p.T34A	LoVo	large intestine	COSMIC	VNPTPGGT	DEG_SCF_FBW7_1	31:38	Mutation altering degron motif	0.7139
p.D381H	SIDM00628	Breast Carcinoma	GDSC	DSGPLS	DEG_SCF_TRCP1_1	389:394	Mutation rewiring degron network	0.1111
p.D381H	MDA-MB-468	breast	COSMIC	DSGPLS	DEG_SCF_TRCP1_1	389:394	Mutation rewiring degron network	0.1111
p.E1166V	SIDM01450	Gastric Carcinoma	GDSC	LRSELAALP	DEG_APCC_DBOX_1	1153:1161	Mutation rewiring degron network	0.1944
p.E1166V	ACH-000898	Gastric Cancer	CCLE	LRSELAALP	DEG_APCC_DBOX_1	1153:1161	Mutation rewiring degron network	0.1944
p.R1143Q	ACH-000520	Ovarian Cancer	CCLE	LRRALGRMV	DEG_APCC_DBOX_1	1141:1149	Mutation altering degron motif	0.6218
p.M1148L	ACH-000896	Bladder Cancer	CCLE	LRRALGRMV	DEG_APCC_DBOX_1	1141:1149	Mutation altering degron motif	0.5999
p.M1148L	647-V	urinary tract	COSMIC	LRRALGRMV	DEG_APCC_DBOX_1	1141:1149	Mutation altering degron motif	0.5999
p.R384H	ACH-002048	Sarcoma	CCLE	DSGPLS	DEG_SCF_TRCP1_1	389:394	Mutation rewiring degron network	0.1944
p.R384H	SNU-1040	large intestine	COSMIC	DSGPLS	DEG_SCF_TRCP1_1	389:394	Mutation rewiring degron network	0.1944
p.P23L	ACH-002059	Leukemia	CCLE	VNPTPGGT	DEG_SCF_FBW7_1	31:38	Mutation rewiring degron network	0.1111
p.P23L	P30-OHK	haematopoietic and lymphoid tissue	COSMIC	VNPTPGGT	DEG_SCF_FBW7_1	31:38	Mutation rewiring degron network	0.1111
p.V383A	ACH-002256	Leukemia	CCLE	DSGPLS	DEG_SCF_TRCP1_1	389:394	Mutation rewiring degron network	0.1667
p.V383A	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	DSGPLS	DEG_SCF_TRCP1_1	389:394	Mutation rewiring degron network	0.1667
p.V383I	YT	haematopoietic and lymphoid tissue	COSMIC	DSGPLS	DEG_SCF_TRCP1_1	389:394	Mutation rewiring degron network	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DHX30

UniProt ID: Q7L2E3

Entrez ID: 22907

Protein name: ATP-dependent RNA helicase DHX30 (EC 3.6.4.13) (DEAH box protein 30)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DHX30 in